全反式维甲酸在成骨分化中作用的研究现状

doi:10.13701/j.cnki.kqyxyj.2018.10.002

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (10): 1038-1041.DOI: 10.13701/j.cnki.kqyxyj.2018.10.002

全反式维甲酸在成骨分化中作用的研究现状

沈晨曦, 毕文娟^*

华北理工大学口腔医学院河北唐山 063200

收稿日期:2017-09-18 出版日期:2018-10-28 发布日期:2018-10-24
通讯作者: 毕文娟,E-mail:bixiaobi2003@163.com
作者简介:沈晨曦(1990~ ),女,河北唐山人,硕士在读,主要从事口腔颌面外科学研究。
基金资助:
国家自然科学基金青年项目(编号:81600844),河北省自然科学基金青年项目(编号:H2017209238),华北理工大学博士科研启动基金(编号:618322jw)

Role of All-trans Retinoic Acid in Osteogenic Differentiation.

SHEN Chen-xi, BI Wen-juan^*.

North China University of Science and Technology, School of Stomatology, Tangshan 063200, China.

Received:2017-09-18 Online:2018-10-28 Published:2018-10-24

摘要/Abstract

摘要： 全反式维甲酸(all-trans retinoic acid, ATRA)可上调多种细胞的成骨相关基因的表达,如成骨细胞、骨髓间充质干细胞等,并可促进细胞基质的矿化。利用ATRA的这种特点能够在临床中减少骨吸收,促进骨形成。但大剂量ATRA则会抑制成骨分化、促进破骨细胞分化,不利于骨质缺损的愈合。本研究就目前国内外关于ATRA对细胞成骨分化的影响研究作一综述。

关键词: 全反式维甲酸, 诱导成骨, 成骨分化

Abstract: All-trans retinoic acid (ATRA) can up-regulate osteoblast-related gene expression of many cells, such as bone marrow stromal cells and osteoblasts. Besides, it can promote mineralization of matrix. The use of this feature of ATRA can reduce bone resorption and promote bone formation in the clinic. However, high dose of ATRA inhibits osteogenic differentiation and promotes osteoclast differentiation, which is not conducive to the healing of bone defects. This study reviews the effects of ATRA on osteogenic differentiation of cells at home and abroad.

Key words: All-trans retinoic acid, Induced osteogenesis, Osteogenic differentiation

沈晨曦, 毕文娟. 全反式维甲酸在成骨分化中作用的研究现状[J]. 口腔医学研究, 2018, 34(10): 1038-1041.

SHEN Chen-xi, BI Wen-juan.. Role of All-trans Retinoic Acid in Osteogenic Differentiation.[J]. Journal of Oral Science Research, 2018, 34(10): 1038-1041.

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全反式维甲酸在成骨分化中作用的研究现状

Role of All-trans Retinoic Acid in Osteogenic Differentiation.

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