牙周炎与动脉粥样硬化信号相互作用的关联影响

doi:10.13701/j.cnki.kqyxyj.2018.12.002

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (12): 1271-1273.DOI: 10.13701/j.cnki.kqyxyj.2018.12.002

牙周炎与动脉粥样硬化信号相互作用的关联影响

黄琳砚¹,赖仁发^1,2*,黄怡^1,2*

1. 暨南大学口腔医学院广东广州 510632;
2. 暨南大学附属第一医院口腔医疗中心种植修复科广东广州 510630

收稿日期:2018-05-31 出版日期:2018-12-28 发布日期:2018-12-27
通讯作者: 赖仁发,E-mail: Prof.Dr.Lai@163.com；黄怡,E-mail: yhuang312@jnu.edu.cn
作者简介:黄琳砚(1986~ ),女,中国台湾人,硕士,主要研究方向为牙周炎及其相关药物研究。
基金资助:
国家自然科学基金青年基金(编号:81603668)；中央高校基本科研业务费专项资金(编号:11616334)

Correlation of Signal Pathway in Periodontitis and Atherosclerosis.

HUANG Lin-yan¹, LAI Ren-fa^1,2*, HUANG Yi^1,2*

1. School of Stomatology, Jinan University, Guangzhou 510632, China;
2. Department of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Received:2018-05-31 Online:2018-12-28 Published:2018-12-27

摘要/Abstract

摘要： 我国65岁以上的老年人牙周炎发病率高达70%以上,近年来随着饮食结构改变,动脉粥样硬化的发病率有逐年升高及年轻化的趋势,大量研究结果显示,慢性牙周炎与动脉粥样硬化之间有共同的风险因素。动脉粥样硬化是心血管疾病主要病因,炎症反应是动脉粥样硬化斑块形成的重要始动因素,而慢性牙周炎作为由微生物引起的慢性多因子炎症性疾病,与动脉粥样硬化的发生有着密不可分的联系。在牙周致病菌中牙龈卟啉单胞菌为慢性牙周炎的主要致病菌,相关毒素可穿过牙龈上皮等进入血液循环,通过长期慢性刺激导致血管内皮细胞功能障碍和激活血液中炎症因子,最终促进血管内斑块的形成。本文简要阐述牙周炎与动脉粥样硬化之间的相关性。

关键词: 动脉粥样硬化, 牙周炎, 牙龈卟啉单胞菌

Abstract: The incidence of chronic periodontitis (CP) is over 70% in the over 65 years old people in China.And the prevalence of atherosclerosis (AS) is increasing with the change of dietary structure.A large number of studies reported that there are common risk factors between CP and AS.CP, a chronic multi-factor inflammatory disease caused by microorganisms, is closely related to AS which is based on chronic infection and is a key basic pathological of cardiovascular disease.Porphyromonas gingivalis (P.g.) is a main periodontal pathogen to CP.From gingival epithelium, P.g.enters the bloodstream, which causes the endothelial dysfunction, releases the inflammatory cytokines, turns macrophages phagocytose lipids into foam cells, and causes the formation of atheroslerotic plaque.This article discussed the association between CP and AS.

Key words: Atherosclerosis, Periodontitis, Porphyromonas gingivalis

黄琳砚,赖仁发,黄怡. 牙周炎与动脉粥样硬化信号相互作用的关联影响[J]. 口腔医学研究, 2018, 34(12): 1271-1273.

HUANG Lin-yan, LAI Ren-fa, HUANG Yi. Correlation of Signal Pathway in Periodontitis and Atherosclerosis.[J]. Journal of Oral Science Research, 2018, 34(12): 1271-1273.

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牙周炎与动脉粥样硬化信号相互作用的关联影响

Correlation of Signal Pathway in Periodontitis and Atherosclerosis.

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