口腔中糖尿病骨病及药物防治的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.03.002

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (3): 208-211.DOI: 10.13701/j.cnki.kqyxyj.2019.03.002

口腔中糖尿病骨病及药物防治的研究进展

苏振宇¹, 张斌^1,2*

1. 哈尔滨医科大学附属第二医院口腔颌面外科黑龙江哈尔滨 150001;
2. 黑龙江省医学科学院黑龙江哈尔滨 150001

收稿日期:2018-05-24 出版日期:2019-03-28 发布日期:2019-04-01
通讯作者: * 张斌,E-mail:zhangbin@hrbmu.edu.cn
作者简介:苏振宇(1992~ ),男,山东烟台人,硕士在读,主要从事口腔颌面外科临床工作。
基金资助:
国家自然科学基金面上项目(编号:81570951)

Research Progress in Oral Diabetic Osteopathy and Drug Control

SU Zhen-yu¹, ZHANG Bin^1,2*

1. Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China;
2. Heilongjiang Academy of Medical Sciences, Harbin 150001, China.

Received:2018-05-24 Online:2019-03-28 Published:2019-04-01

摘要/Abstract

摘要： 糖尿病骨病是一种危害极大的糖尿病并发症,其发病率呈逐年上升趋势。糖尿病导致的慢性高血糖会增加全身骨质疏松及骨折的发生风险。在口腔中可表现为牙周炎、牙槽骨丧失及种植体骨结合失败等,目前其发病机制尚未完全明确。对口腔中糖尿病骨病的研究更多集中于药物治疗的选择。而在实际临床应用中,应该根据药物的不良反应和疾病的严重程度选择合适的药物,确定适当的给药剂量和疗程,最终使患者获得最佳的治疗效果。

关键词: 糖尿病骨病, 口腔, 药物防治

Abstract: Diabetic bone disease is a devastating complication of diabetes, and its incidence rate has been increased year by year. Chronic hyperglycemia caused by diabetes can increase the risk of systemic osteoporosis and fractures. In the oral cavity, it can manifest as periodontitis, loss of alveolar bone, and implant bone failure. At present, its pathogenesis is not completely clear. The study of oral diabetic bone disease focuses more on the choice of drug therapy. In the actual clinical application, drugs should be selected according to the adverse reactions of the drugs and the severity of the disease, and the appropriate dose and treatment course should be determined so that the patient can obtain the best therapeutic effect.

Key words: Diabetic bone disease, Oral, Drug control

苏振宇, 张斌. 口腔中糖尿病骨病及药物防治的研究进展[J]. 口腔医学研究, 2019, 35(3): 208-211.

SU Zhen-yu, ZHANG Bin. Research Progress in Oral Diabetic Osteopathy and Drug Control[J]. Journal of Oral Science Research, 2019, 35(3): 208-211.

参考文献

[1] American Diabetes Association. Erratum. Classification and diagnosis of diabetes. Sec. 2. In Standards of Medical Care in Diabetes-2016. Diabetes Care 2016;39(Suppl. 1):S13-S22[J]. Diabetes care,2016,39(9):1653.
[2] Jackuliak P, Payer J. Osteoporosis, fractures, and diabetes [J]. Int J Endocrinol, 2014,2014:820615.
[3] Epstein S, Defeudis G, Manfrini S, et al. Diabetes and disordered bone metabolism (diabetic osteodystrophy): time for recognition [J]. Osteoporos Int, 2016, 27(6):1931-1951.
[4] Piscitelli P, Neglia C, Vigilanza A. Diabetes and bone: biological and environmental factors [J]. Curr Opin Endocrinol Diabetes Obes, 2015, 22(6):439-445.
[5] Bacevic M, Brkovic B, Albert A, et al. Does oxidative stress play a role in altered characteristics of diabetic bone? a systematic review [J]. Calcif Tissue Int, 2017, 101(6):553-563.
[6] Joshipura KJ, Muñoz-Torres FJ, Dye BA, et al. Longitudinal association between periodontitis and development of diabetes[J]. Diabetes Res Clin Pract, 2018, 141:284-293.
[7] 闫艳梅,唐亚平,贺涛,等.1,25(OH)₂D₃对2型糖尿病伴牙周炎患者中性粒细胞凋亡及炎性介质表达的影响[J].口腔医学研究,2017,33(3):269-272.
[8] Lakschevitz F, Aboodi G, Tenenbaum H. Diabetes and periodontal diseases: interplay and links [J]. Curr Diabetes Rev, 2011, 7(6):433-439.
[9] Tóthová L. Oxidative stress and antioxidants in the diagnosis and therapy of periodontitis [J]. Front Physiol, 2017, 8:1055.
[10] Engebretson S. Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis [J]. J Periodontol, 2013, 84(4 Suppl):S153-S169.
[11] King S, Klineberg I, Levinger I. The effect of hyperglycaemia on osseointegration: a review of animal models of diabetes mellitus and titanium implant placement [J]. Arch Osteoporos, 2016, 11(1):29.
[12] Chrcanovic BR, Albrektsson T. Diabetes and oral implant failure: a systematic review [J]. J Dent Res, 2014, 93(9):859-867.
[13] Katyayan PA,Katyayan M. Rehabilitative considerations for dental implants in the diabetic patient [J]. J Indian Prosthodont Soc, 2013, 13(3):175-183.
[14] Annibali S, Pranno N, Cristalli MP, et al. Survival analysis of implant in patients with diabetes mellitus: a systematic review [J]. Implant Dent, 2016, 25(5):663-674.
[15] Naujokat H, Kunzendorf B. Dental implants and diabetes mellitus-a systematic review [J]. Int J Implant Dent, 2016, 2(1):5.
[16] Dubey RK, Gupta DK. Dental implant survival in diabetic patients; review and recommendations [J]. Natl J Maxillofac Surg, 2013, 4(2):142-150.
[17] Gómez-Moreno G, Aguilar-Salvatierra A, Rubio Roldán J, et al. Peri-implant evaluation in type 2 diabetes mellitus patients: a 3-year study [J]. Clin Oral Implants Res, 2015, 26(9):1031-1035.
[18] Borba AM, Souza DF, Brozoski MA, et al.Can the use of antibiotics interfere with the success of dental osseointegrated implants in diabetic patients [J]. J Contemp Dent Pract, 2013, 14(6):1197-1201.
[19] Malekzadeh BÖ,Erlandsson MC, Tengvall P, et al. Effects of implant-delivered insulin on bone formation in osteoporotic rats [J]. J Biomed Mater Res A, 2018, 106(9):2472-2480.
[20] Wu YY, Yu T, Yang XY, et al. Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats [J]. Bone, 2013, 52(1):1-8.
[21] Hua N, Xu Y, Tang X, et al. Effect of estrogen deficiency on implant osseointegration in dogs [J]. Int J Oral Maxillofac Implants, 2014, 29(5):1204-1207.
[22] Xu R, Shi G, Xu L, et al. Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity [J]. J Tissue Eng Regen Med, 2018, 12(5):1209-1219.
[23] Liporace FA, Breitbart EA, Yoon RS, et al. The effect of locally delivered recombinant human bone morphogenetic protein-2 with hydroxyapatite/tri-calcium phosphate on the biomechanical properties of bone in diabetes-related osteoporosis [J]. J Orthop Traumatol, 2015, 16(2):151-159.
[24] Cankaya D, Tabak Y, Ozturk AM. Perioperative alendronate, risedronate, calcitonin and indomethacin treatment alters femoral stem fixation and periprosthetic bone mineral density in ovariectomized rats [J]. J Orthop Sci, 2015, 20(4):728-733.
[25] Dikicier E, Karaçayli Ü,Dikicier S.Effect of systemic administered zoledronic acid on osseointegration of a titanium implant in ovariectomized rats [J]. J Craniomaxillofac Surg, 2014, 42:1106-1111.
[26] Xiong Y, Zhang Y, Guo Y, et al. 1α,25-Dihydroxyvitamin D increases implant osseointegration in diabetic mice partly through FoxO1 inactivation in osteoblasts [J]. Biochem Biophys Res Commun, 2017, 494(3-4):626-633.
[27] Hu XF, Wang L, Lu YZ, et al. Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro [J]. Acta Biomater, 2017, 61:233-248.
[28] Yang Y, Zhao C, Liang J, et al. Effect of dipeptidyl peptidase-4 inhibitors on bone metabolism and the possible underlying mechanisms [J]. Front Pharmacol,2017,8:487.

口腔中糖尿病骨病及药物防治的研究进展

Research Progress in Oral Diabetic Osteopathy and Drug Control

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