光动力疗法在口腔念珠菌病中的应用前景及研究进展

doi:10.13701/j.cnki.kqyxyj.2020.12.002

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (12): 1087-1090.DOI: 10.13701/j.cnki.kqyxyj.2020.12.002

光动力疗法在口腔念珠菌病中的应用前景及研究进展

韦帝远, 闫志敏^*

北京大学口腔医院口腔黏膜科北京 100081

收稿日期:2019-11-20 出版日期:2020-12-28 发布日期:2020-12-28
通讯作者: *闫志敏,E-mail:yzhimin96@163.com
作者简介:韦帝远(1996~ ),男,广西南宁人,硕士在读,主要从事口腔内科学相关研究。
基金资助:
国家自然科学基金(编号:81570985)

Research Progress and Application Potential of Photodynamic Therapy in Treating Oral Candidiasis

WEI Diyuan, YAN Zhimin^*

Department of Oral Medicine, Peking University School of Stomatology, Beijing 100081,China

Received:2019-11-20 Online:2020-12-28 Published:2020-12-28

摘要/Abstract

摘要： 光动力疗法(photodynamic therapy,PDT)是一种利用光敏剂通过光动力反应产生单线态氧而选择性地抗肿瘤、抗微生物的精准靶向疗法。近年来随着PDT在临床不断推广应用,其抗念珠菌作用日益受到关注。与传统抗真菌药物治疗相比,PDT具有作用机制及疗效较明确,不产生耐药性等优势,在口腔念珠菌病的治疗中显示出潜在应用价值。本文将从PDT抗念珠菌的作用机理、影响因素、临床研究疗效、安全性以及适用范围等角度对其在口腔念珠菌病中研究进展及应用前景进行综述。

关键词: 光动力疗法, 口腔念珠菌, 治疗效果, 安全性

Abstract: Photodynamic therapy (PDT) is a precision targeted therapy that produces singlet oxygen through photodynamic reaction to exert selectively anti-tumor and anti-microbial activity. With the broadened clinical application in recent years, PDT's anti-candida effect has attracted more attention. Compared with traditional antifungal agents, PDT has relatively definite mechanism and curative effect, and does not lead to resistance, which exhibits clinical potential in the treatment of oral candidiasis. Here we conduct a comprehensive review of the current knowledge of mechanisms, influence factors, clinical effectiveness and safety, research progress, and application potential of PDT in treating oral candidiasis.

Key words: photodynamic therapy, oral candidiasis, effectiveness, safety

韦帝远, 闫志敏. 光动力疗法在口腔念珠菌病中的应用前景及研究进展[J]. 口腔医学研究, 2020, 36(12): 1087-1090.

WEI Diyuan, YAN Zhimin. Research Progress and Application Potential of Photodynamic Therapy in Treating Oral Candidiasis[J]. Journal of Oral Science Research, 2020, 36(12): 1087-1090.

参考文献

[1] Jeffery-Smith A, Taori SK, Schelenz S, et al. Candida auris: a review of the literature [J]. Clin Microbiol Rev, 2018, 31(1):e00029-17.
[2] Rabb O. Uber die wirkung fluoreszierender stoffe auf infusorien [J]. Z Biol, 1900, 39: 524-546.
[3] Baltazar LM, Ray A, Santos DA, et al. Antimicrobial photodynamic therapy: an effective alternative approach to control fungal infections [J]. Front Microbiol, 2015, 6:202.
[4] Donnelly RF, Mccarron PA, Tunney MM. Antifungal photodynamic therapy [J]. Microbiol Res, 2008, 163(1):1-12.
[5] Kashef N, Hamblin MR. Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation [J]. Drug Resist Updat, 2017, 31:31-42.
[6] Liyi H, Brijesh B, Weijun X, et al. Comparison of two functionalized fullerenes for antimicrobial photodynamic inactivation: Potentiation by potassium iodide and photochemical mechanisms [J]. J Photochem Photobiol B, 2018, 186:197-206.
[7] Freire F, Ferraresi C, Jorge AO, et al. Photodynamic therapy of oral Candida infection in a mouse model [J]. J Photochem Photobiol B, 2016, 159:161-168.
[8] Prates RA, Kato IT, Ribeiro MS, et al. Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans [J]. J Antimicrob Chemother, 2011, 66(7):1525-1532.
[9] Teichert MC, Jones JW, Usacheva MN, et al. Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 93(2):155-160.
[10] Mima EG, Pavarina AC, Silva MM, et al. Denture stomatitis treated with photodynamic therapy: five cases [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(5):602-608.
[11] Abduljabbar T, Al-Askar M, Baig MK, et al. Efficacy of photodynamic therapy in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis [J]. Photodiagnosis Photodyn Ther, 2017, 18:50-53.
[12] Mima EG, Vergani CE, Machado AL, et al. Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial [J]. Clin Microbiol Infect, 2012, 18(10):E380-E388.
[13] de Senna AM, Vieira MMF, Machado-De-Sena RM, et al. Photodynamic inactivation of, Candida, ssp. on denture stomatitis: A clinical trial involving palatal mucosa and prosthesis disinfection [J]. Photodiagnosis Photodyn Ther, 2018, 22: 212-216.
[14] Maciel CM, Piva MR, Ribeiro MA, et al. Methylene blue-mediated photodynamic inactivation followed by low-laser therapy versus miconazole gel in the treatment of denture stomatitis [J]. J Prosthodont, 2016, 25(1):28-32.
[15] Scwingel AR, Barcessat AR, Núñez SC, et al. Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients [J]. Photomed Laser Surg, 2012, 30(8):429-432.
[16] 全昌园.抗菌光动力疗法(APDT)对AIDS合并口腔白色念珠菌病临床疗效观察[D].南宁:广西医科大学,2017.
[17] 赵玥,覃金梅,黄力毅.二甲基蓝介导的光动力抗菌疗法对AIDS合并口腔白色念珠菌病的疗效观察[J].广西医科大学学报,2018,35(2):178-180.
[18] 覃金梅.光动力疗法对AIDS患者口腔白色念珠菌病的抗菌效应研究[D].南宁:广西医科大学,2018.
[19] Teichert MC, Jones JW, Usacheva MN, et al. Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 93(2):155-160.

光动力疗法在口腔念珠菌病中的应用前景及研究进展

Research Progress and Application Potential of Photodynamic Therapy in Treating Oral Candidiasis

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