微小RNA调控牙周膜干细胞成骨分化的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.03.004

摘要/Abstract

摘要： 牙周炎是一种常见的慢性感染性疾病,可导致牙周支持组织的进行性破坏。牙周膜干细胞具有成骨向分化能力,在牙周组织再生领域中拥有广阔的应用前景。微小RNA(microRNA, miRNA)是长度约18~25个核苷酸的非编码单链RNA,可靶向mRNA 3’非翻译区(untranslated region, UTR),进而导致mRNA降解或抑制mRNA翻译。近年来许多学者都在研究miRNA的成骨调控作用,且多种miRNAs已经被证实参与牙周膜干细胞的成骨调控,本文就目前miRNA调控牙周膜干细胞成骨分化的研究进展作一综述。

关键词: 微小RNA, 牙周膜干细胞, 成骨分化, 外泌体

Abstract: Periodontitis is a common chronic infectious disease, which can lead to the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells have the ability of osteogenic differentiation, which have broad application prospects in the field of periodontal tissue regeneration. MicroRNA (miRNA) is a non-coding single stranded RNA with a length of 18-25 nucleotides. It can target the 3 'untranslated region (UTR) of mRNA, resulting in degradation of mRNA or inhibition of mRNA translation. In recent years, many scholars have studied the osteogenic regulation of miRNA, and a variety of miRNA have been confirmed to be involved in the osteogenic regulation of periodontal ligament stem cells. In this paper, the current research progress of miRNA in regulating the osteogenic differentiation of periodontal ligament is reviewed.

Key words: microRNA, periodontal ligament stem cells, osteogenic differentiation, exosome

赵军, 刘丽娜. 微小RNA调控牙周膜干细胞成骨分化的研究进展[J]. 口腔医学研究, 2022, 38(3): 220-222.

ZHAO Jun, LIU Lina. Research Progress of MicroRNA in Osteogenic Differentiation of Periodontal Ligament Stem Cells[J]. Journal of Oral Science Research, 2022, 38(3): 220-222.

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