牙周炎通过菌群作用促进类风湿关节炎的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.05.003

摘要/Abstract

摘要： 牙周炎是由菌斑微生物引发的多因素参与的炎症性疾病。类风湿关节炎是以慢性炎症和关节组织破坏为主要表现的全身免疫性疾病。牙周炎和类风湿关节炎在病理过程和破坏机制上具有相似性,包括骨破坏、软组织炎症及受相似环境因素等影响。近年来,肠道菌群在系统性疾病中的作用日益受到关注,牙周病原菌可能通过吞咽进入肠道影响肠道微生态,肠道菌群失调会进一步促进关节炎的发生发展。本文主要就牙周炎与类风湿关节炎之间可能通过肠道菌群发生的相互作用及相关机制进行综述,以期为牙周炎和类风湿关节炎潜在的相关机制研究提供新思路。

关键词: 牙周炎, 类风湿关节炎, 肠道菌群

Abstract: Periodontitis is an immunoinflammatory disease with multifactorial involvement caused by plaque microorganisms. Rheumatoid arthritis is a systemic immune disease characterized by chronic inflammation and destroy in joint tissues. Both diseases share similarities in pathological processes and mechanisms of tissue destruction, including bone destruction, soft tissue inflammation, and the influence of the same environmental factors etc. In recent years, increasing attention has been put on the role of gut microbiota dysbiosis in systemic diseases, where periodontal pathogenic bacteria may enter the intestine through swallowing to affect gut microecology. Dysbiosis of gut microbiota can further aggravate the development of arthritis. The purpose of this review is to reveal the possible effects of gut microbiota on interactions between periodontitis and rheumatoid arthritis through the gut microbiota, as well as the related mechanism. Hopefully, this review will identify new insights on the relationship between periodontitis and rheumatoid arthritis.

Key words: periodontitis, rheumatoid arthritis, gut microbiota

刘蓉, 杨琨. 牙周炎通过菌群作用促进类风湿关节炎的研究进展[J]. 口腔医学研究, 2023, 39(5): 392-395.

LIU Rong, YANG Kun. Research Progress of Periodontitis Aggravating Rheumatoid Arthritis by Flora[J]. Journal of Oral Science Research, 2023, 39(5): 392-395.

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