机械刺激对牙周膜干细胞生物学行为的影响

doi:10.13701/j.cnki.kqyxyj.2023.05.004

摘要/Abstract

摘要： 牙周膜干细胞(periodontal ligament stem cells, PDLSCs)在治疗牙周疾病和其他组织再生领域具有较大的应用前景,对于其生物学行为的研究有助于再生医学领域的发展。机械刺激如机械应力、基质表面形貌及弹性不仅影响了PDLSCs的增殖、迁移,还具有诱导其向骨、肌腱、心肌、角膜等体细胞分化的潜能,且这一过程受到各种因素的调控。此外,PDLSCs对机械刺激的感知还具有记忆性,PDLSCs能保留过去培养环境中的机械信息,并影响其未来的分化方向。目前研究已证实PDLSCs的机械刺激信号可以通过整合素和离子通道传递至细胞内,进而调节细胞行为。本文以机械刺激对PDLSCs生物学行为的影响作一综述,以期为组织工程中PDLSCs分化调控提供新思路。

关键词: 牙周膜干细胞, 机械刺激, 细胞分化, 整合素, 压电蛋白

Abstract: Periodontal ligament stem cells (PDLSCs) have great potential in the treatment of periodontal diseases and other tissue regeneration fields, and the study of their biological behavior is helpful to the development of regenerative medicine. Mechanical stimuli such as mechanical stress, matrix surface morphology, and elasticity not only affect the proliferation and migration of PDLSCs, but also have the potential to induce the differentiation of PDLSCs into bone, tendon, myocardium, cornea, and other somatic cells, and this process is regulated by the time dimension. In addition, the perception of PDLSCs to mechanical stimuli also has memory. PDLSCs can retain the mechanical information in the past culture environment and affect the direction of their future differentiation. Current studies have confirmed that mechanical stimulation signals of PDLSCs can be transmitted into cells through integrins and ion channels to regulate cell behavior. In this paper, the effects of mechanical stimulation on the biological behavior of PDLSCs are reviewed, in order to provide new ideas for the regulation of PDLSCs differentiation in tissue engineering.

Key words: periodontal ligament stem cells, mechanical stimulation, cell differentiation, integrin, piezo protein

王晓莉, 安晓莉. 机械刺激对牙周膜干细胞生物学行为的影响[J]. 口腔医学研究, 2023, 39(5): 396-401.

WANG Xiaoli, AN Xiaoli. Effects of Mechanical Stimulation on Biological Behavior of Periodontal Ligament Stem Cells[J]. Journal of Oral Science Research, 2023, 39(5): 396-401.

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