金属有机框架在牙周炎领域的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.08.001

摘要/Abstract

摘要： 金属有机框架(metal-organic frameworks,MOFs)是一种新型固体晶态多孔功能材料,由有机配体和配位金属离子/离子簇组成,被广泛应用于生物医学领域,包括药物载体、种植体表面涂层改性、储存气体、传感和生物成像等。牙周炎是一种由牙周致病菌、遗传易感性、宿主免疫反应等多因素引起的慢性炎症性疾病。本文围绕MOFs的合成策略、药物装载策略、牙周炎相关的MOFs类型及其在牙周炎应用的作用机制4个方面对MOFs在牙周炎领域的研究进展作一综述。

关键词: 金属有机框架, 牙周炎, 金属有机框架制备, 金属有机框架生物医学特性

Abstract: Metal-organic frameworks (MOFs) are a new type of solid crystalline porous functional materials, which are composed of organic ligands and coordinated metal ions/ion clusters. MOFs are widely used in biomedical fields, including drug delivery, implant surface coating modification, gas storage, sensing, and biological imaging. Periodontitis is a chronic inflammatory disease caused by periodontal pathogens, genetic susceptibility, host im-mune response, and other factors. This article reviews the research progress of MOFs in the field of periodontitis from four aspects: synthesis strategy of MOFs, drug loading strategy, types of MOFs related to periodontitis, and their mechanisms of action in periodontitis.

Key words: metal-organic framework, periodontitis, preparation of MOFs, biomedical properties of MOFs

江珍, 刘志辉. 金属有机框架在牙周炎领域的研究进展[J]. 口腔医学研究, 2025, 41(8): 641-646.

JIANG Zhen, LIU Zhihui. Research Progress of Metal-organic Frameworks in the Field of Periodontitis[J]. Journal of Oral Science Research, 2025, 41(8): 641-646.

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