HMGB 1在舌鳞状上皮癌中的表达及临床意义

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (10): 1040-1042.

HMGB 1在舌鳞状上皮癌中的表达及临床意义

李敬^*,邹廷前,王伟,李成锋,曾涛

荆门市第二人民医院口腔科湖北荆门 448000

收稿日期:2015-05-11 出版日期:2015-10-28 发布日期:2016-05-04
通讯作者: 李敬,电话:0724-6903087
作者简介:李敬(1974~ ),副主任医师,硕士,主要从事口腔颌面外科临床及研究工作。
基金资助:
湖北省自然科学基金项目(编号:2014CFC1030)

Expression of HMGB1 in Tongue Squamous Cell Carcinoma

LI Jing, ZOU Tin-qian, WANG Wei, LI Chen-feng, ZENG Tao

Department of Stomatology, The Second People’s Hospital. Jingmen 448000, China

Received:2015-05-11 Online:2015-10-28 Published:2016-05-04

摘要/Abstract

摘要： 目的:探讨舌鳞癌中高迁移率族蛋白1(HMGB1)的表达及其对淋巴结转移和疾病转归的关系。方法:收集51例有完整临床及随访资料的舌鳞癌石蜡标本,采用免疫组织化学染色法观察HMGB1在不同分类的口腔鳞癌组织中的表达,并分析HMGB1与肿瘤分化程度、淋巴结转移及患者预后之间的关系。结果:HMGB1在舌鳞癌组织中呈高表达,阳性率92.2%;HMGB1表达与肿瘤分化程度在统计学上无显著相关性;有淋巴结转移的高表达率为81.2% ,无淋巴结转移的高表达率为32.6%,其差异具有统计学意义(P＜0.05)。高表达HMGB1的舌鳞癌患者较低表达者转归差,其生存率较低(P＜0.05)。结论:舌鳞癌组织中HMGB1与淋巴结转移及转归密切相关; HMG1的表达在一定程度上可用作反映舌鳞癌预后的重要生物学指标。

关键词: 高迁移率族蛋白1, 舌鳞癌, 淋巴转移

Abstract: Objective: To investigate the expression and biological significance of HMGB1 proteinin tissue specimens of tongue squamous cell carcinoma (TSCC), and study the correlation between HMGB1 and clinical features of the patients. Methods: The expression of HMGB1 protein was evaluated by immunohistochemical staining in 51 cases of TSCC specimens and further correlated with clinical pathologic parameters of the patients using statistical methods. Results: The positive rates of HMGB1 in TSCC tissues were 92.2%. The expression of HMGB1 was not significantly correlated with tumor histological differentiation, however it was closely correlated with lymph node metastasis (P<0.05) in TSCC. There were 81.2% high expression of HMGB1 in lymph node metastasis, while only 32.6 % in no metastasis cases. The Kaplan-Meier survival analysis showed that patients with strong expression of HMGB1 had poorer overall survival rate compared with that in patients with relatively low HMGB1 expression (P<0.05) . Conclusion: HMGB1 over-expression was closely associated with metastasis and poorer prognosis inpatients with TSCC.

Key words: High mobility group box -1 protein, Tongue squamous cell carcinoma, Lymph node metastasis

中图分类号:

R739.8

李敬,邹廷前,王伟,李成锋,曾涛. HMGB 1在舌鳞状上皮癌中的表达及临床意义[J]. 口腔医学研究, 2015, 31(10): 1040-1042.

LI Jing, ZOU Tin-qian, WANG Wei, LI Chen-feng, ZENG Tao. Expression of HMGB1 in Tongue Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2015, 31(10): 1040-1042.

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