口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (4): 388-392.

• 临床研究论著 • 上一篇    下一篇

基质金属蛋白酶2在中国人口腔鳞状细胞癌中表达的Meta分析

朱丽芳1, 易安华2,3*   

  1. 1. 武汉科技大学附属天佑医院整形美容科 湖北 武汉 430064;
    2. 湖北省口腔基础医学重点实验室-省部共建国家重点实验室培育基地;
    3. 武汉大学口腔生物医学教育部重点实验室)
  • 收稿日期:2014-10-23 出版日期:2015-04-28 发布日期:2016-04-29
  • 通讯作者: 易安华,电话:027-87686278
  • 作者简介:朱丽芳(1963~ ),女,湖北人,学士,主管护师,主要从事口腔医学的临床治疗工作。

Meta-analysis of the Relevance between MMP2 Protein and Oral Squamous Cell Carcinoma in China.

ZHU Li-fang, YI An-hua   

  1. The State Key Laboratory Breeding Base of Basic Scienceof Stomatology, Hubei Province & Key Laboraroty of Oral Biomedicine, Ministry of Education, Wuhan University, Wuhan 430079
  • Received:2014-10-23 Online:2015-04-28 Published:2016-04-29

摘要： 目的:建立基质金属蛋白酶2(Matrix Metallo Proteinase 2,MMP2)在中国人口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)中表达的相关性。方法:查找中国学术期刊网络出版总库、中国生物医学文献数据库、万方数据库和重庆维普中文科技期刊全文数据库等网上的在线数据库,获取1990年1月~2014年10月国内专业期刊杂志发表的相关原始文献进行Meta分析。结果:达到Meta分析要求的研究总计15个,OSCC组685例,正常口腔黏膜(Normal Oral Mucous, NOM)组275例,Meta分析结果表明MMP2在OSCC组中的表达大于NOM组,呈显著性(OR值等于13.26,95%CI范围为9.02~19.50,P值小于0.05)。结论:根据现有的MMP2和OSCC相关研究的Meta分析结果,MMP2高表达是OSCC的侵袭转移的关键因子。

关键词: MMP2, OSCC, Meta分析

Abstract: Objective: To explore the relevance between MMP2 Protein expression and Oral squamous cell carcinoma in China. Methods: The CNKI, CBM, Wangfang and VIP Database were searched to collect published literature from 1990 to 2014 and meta-analysis was done. Results: 15 publications were finally included in this study. There were 685 cases of OSCC and 275 normal controls. The OR was 13.26, and the 95%CI was 9.02-19.50. Conclusions: Based on research results at present, the high expression of MMP2 protein plays a important role in the development of oral squamous cell carcinoma.

Key words: MMP2 , OSCC , Meta analysis

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