白细胞介素-1β基因T-31C多态性与牙周炎易感性的Meta分析

doi:10.13701/j.cnki.kqyxyj.2017.04.010

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (4): 386-389.DOI: 10.13701/j.cnki.kqyxyj.2017.04.010

白细胞介素-1β基因T-31C多态性与牙周炎易感性的Meta分析

甲成^1*, 李晓燕¹, 孙凤², 夏凌云³, 曾宪涛⁴

1. 河北医科大学第三医院正畸科河北石家庄 050051;
2. 北京大学公共卫生学院流行病与卫生统计学系北京 100191;
3. 湖北医药学院附属太和医院口腔科湖北十堰 442000;
4. 武汉大学中南医院循证与转化医学中心湖北武汉 430071

收稿日期:2016-08-29 出版日期:2017-04-20 发布日期:2017-04-24
通讯作者: 甲成,E-mail: 18533112922@163.com
作者简介:甲成(1970～ ),男,山东济南人,硕士,主要从事口腔正畸及牙周组织工程的研究。
基金资助:
国家自然科学基金项目(编号:81302508)

Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility.

JIA Cheng^1*, LI Xiao-yan¹, SUN Feng², XIA Ling-yun³, ZENG Xian-tao⁴.

1. Department of Orthodontics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China;
2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China;
3. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
4. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Received:2016-08-29 Online:2017-04-20 Published:2017-04-24

摘要/Abstract

摘要： 目的:应用Meta分析的方法评价白细胞介素-1β(IL-1β)基因T-31C多态性与牙周炎易感性之间的关系。方法:全面检索PubMed、Embase和中国知网,检索时间截至2016年5月26日。由2位研究者独立筛选文献和提取数据后,采用Comprehensive Meta-Analysis v2 软件进行Meta分析。结果:最终纳入8项病例-对照研究,结果显示5种基因模型均未发现IL-1β基因T-31C多态性与牙周炎易感性之间存在相关性。敏感性分析证实总体结果稳健性良好,亚组分析与总体研究的结果也基本一致。结论:当前证据尚不能证实IL-1β基因T-31C多态性与牙周炎易感性之间存在相关性。

Abstract: Objective: To investigate the association between interleukin-1β (IL-1β) T-31C polymorphism and periodontitis risk using a meta-analysis. Methods: A comprehensive literature search from PubMed, Embase and Chinese National Knowledge Infrastructure up to May 26, 2016 was made. Two authors selected the studies and extracted data, and then the meta-analysis was conducted using the Comprehensive Meta-Analysis v2 software. Results: Finally eight case-control studies were yielded. All five genetic models revealed non-significant association between the IL-1β T-31C polymorphism and periodontitis risk. Sensitivity analysis indicated that the results were robust and the subgroup analysis yielded similar results. Conclusion: Based on current evidence, the IL-1β T-31C polymorphism was not associated with PD susceptibility in overall population.

Key words: Interleukin-1, Periodontitis , Polymorphism , Meta-analysis

中图分类号:

R781.4

甲成, 李晓燕, 孙凤, 夏凌云, 曾宪涛. 白细胞介素-1β基因T-31C多态性与牙周炎易感性的Meta分析[J]. 口腔医学研究, 2017, 33(4): 386-389.

JIA Cheng, LI Xiao-yan, SUN Feng, XIA Ling-yun, ZENG Xian-tao.. Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility.[J]. Journal of Oral Science Research, 2017, 33(4): 386-389.

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白细胞介素-1β基因T-31C多态性与牙周炎易感性的Meta分析

Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility.

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