miRNAs在牙周领域中的研究进展

doi:10.13701/j.cnki.kqyxyj.2017.09.026

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (9): 1016-1018.DOI: 10.13701/j.cnki.kqyxyj.2017.09.026

• 综述 • 上一篇

miRNAs在牙周领域中的研究进展

薛楠，戚琳，刘欢叶，张扬^*

中国医科大学附属口腔医院正畸科辽宁沈阳 110002

收稿日期:2016-05-19 出版日期:2017-09-20 发布日期:2017-09-27
通讯作者: 张扬,电话:(024)31927707
作者简介:薛楠(1985~ ),女,辽宁省沈阳人,主治医师,硕士,主要从事口腔医学方面研究。
基金资助:
辽宁省教育厅基金资助项目(编号:L2014303)

Research Progress of MicroRNAs in Field of Periodontics

XUE Nan, QI Lin, LIU Huan-ye, ZHANG Yang^*

Department of Orthodontics, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang 110002, China.

Received:2016-05-19 Online:2017-09-20 Published:2017-09-27

摘要/Abstract

摘要： 微小分子RNA(microRNAs,miRNAs)是一类内源性非编码小分子RNA,miRNAs在基因表达调控方面具有广泛和普遍的作用,参与了细胞增殖、细胞分化、生物体发生发育等生物学过程.目前对于miRNAs的研究主要集中在肿瘤方面,对于口腔牙周领域的研究甚少,本文根据miRNAs与牙周组织研究的最新进展,就其在牙周炎症性疾病以及成骨、破骨分化中的异常表达及可能机制方面作一论述。

关键词: miRNA, 牙周炎, 成骨分化, 破骨分化

Abstract: MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that regulate gene expression. It plays a critical role in cell proliferation, cell differentiation, and organism development. Current researches on miRNAs mainly focus on its antitumor effect while its role in periodontics lacks attention. This review is focusing on the differential expression of miRNAs in periodontitis, osteoblast, and osteoclast differentiation, and discussing their possible regulation mechanism on the basis of the latest progress on researches of miRNAs in periodontitis.

Key words: MiRNA Periodontitis , Osteoblast differentiation, Osteoclast differentiation

中图分类号:

R781.4

薛楠，戚琳，刘欢叶，张扬. miRNAs在牙周领域中的研究进展[J]. 口腔医学研究, 2017, 33(9): 1016-1018.

XUE Nan, QI Lin, LIU Huan-ye, ZHANG Yang. Research Progress of MicroRNAs in Field of Periodontics[J]. Journal of Oral Science Research, 2017, 33(9): 1016-1018.

参考文献

[1] Ponomarev ED, Veremeyko T, Weiner HL. MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS [R]. Glia, 2013, 61(1)∶91-103
[2] Wang YL, He H, Liu ZJ, et al. Effects of TNF-α on Cementoblast Differentiation, Mineralization, and Apoptosis [J]. J Dent Res, 2015, 94(9)∶1225-1232
[3] Lee YH, Na HS, Jeong SY. Comparison of inflammatory microRNA expression in healthy and periodontitis tissues [J]. Biocell, 2011, 35(2)∶43-49
[4] Xie YF, Shu R, Jiang SY, et al. Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues [J]. Int J Oral Sci, 2011, 3(3)∶125-134
[5] Stoecklin-Wasmer C, Guarnieri P, Celenti R, et al. MicroRNAs and their target genes in gingival tissues [J]. J Dent Res, 2012, 91(10)∶934-940
[6] Perri R, Nares S, Zhang S, et al. MicroRNA modulation inobesity and periodontitis [J]. J Dent Res, 2012, 91(1)∶33-38
[7] Wang J, Bai X, Song Q, et al. miR-223 Inhibits Lipid Deposition and Inflammation by Suppressing Toll-Like Receptor 4 Signaling in Macrophages [J]. Int J MolSci, 2015, 16(10)∶24965-24982
[8] Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [J]. ProcNatlAcadSci U S A, 2006, 103(33)∶12481-12486
[9] Bhaumik D, Scott GK, Schokrpur S, et al. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells [J]. Oncogene, 2008, 27(42)∶5643-5647
[10] Qi J, Qiao Y, Wang P, et al. microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophages [J]. FEBS Lett, 2012, 586(8)∶1201-1207
[11] Qi L, Zhang Y.The microRNA 132 regulates fluid shear stress-induced differentiation in periodontal ligament cells through mTOR signaling pathway [J]. Cell PhysiolBiochem, 2014, 33(2)∶433-445
[12] Chang M, Lin H, Luo M, et al. Integrated miRNA and mRNA expression profiling of tension force-induced bone formation in periodontal ligament cells [J]. In Vitro Cell DevBiolAnim, 2015,51(8)∶797-807
[13] 章燕,甄蕾,郭姜莉.牙周膜干细胞成骨分化前后miRNA表达谱差异分析[J]. Chinese Journal of Practical Stomatology, 2013, 6(3)∶148-152
[14] Dobreva G, Chahrour M, Dautzenberg M, et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation [J]. Cell, 2006, 125(5)∶971-986
[15] 吕红兵.应用基因芯片分析牙周膜干细胞向成骨细胞分化过程中miRNA表达谱的差异[J].中国医学工程,2014,22(5)∶3-4
[16] 章燕,甄蕾,郭姜莉.人牙周膜干细胞成骨分化前后miRNA表达谱差异分析[J].中国实用口腔科杂志,2013,6(3)∶148-152
[17] Liu Y, Liu W, Hu C, et al. MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis [J]. Stem Cells, 2011, 29(11)∶1804-1816
[18] Li C, Li C, Yue J, et al. miR-21 and miR-101 regulate PLAP-1 expression in periodontal ligament cells [J]. Mol Med Rep, 2012, 5(5)∶1340-1346
[19] Hung PS, Chen FC, KuangSH, et al. miR-146a induces differentiation of periodontal ligament cells [J]. J Dent Res, 2010, 89(3)∶252-257
[20] Franceschetti T, Kessler CB, Lee SK, et al. miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration [J]. J BiolChem, 2013, 288(46)∶33347-33360
[21] Cheng P, Chen C, He HB, et al. J miR-148a regulates osteoclastogenesis by targeting V-mafmusculoaponeuroticfibrosarcoma oncogene homolog B [J]. Bone Miner Res, 2013, 28(5)∶1180-1190
[22] Zhao C, Sun W, Zhang P, et al. miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway [J]. RNA Biol, 2015, 12(3)∶343-353
[23] Guo LJ, Liao L, Yang L, et al. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis [J]. Exp Cell Res, 2014, 321(2)∶142-152
[24] Holdt LM, Teupser D. Long noncoding RNA-MicroRNA pathway controlling nuclear factor IA, a novel atherosclerosis modifier gene [J]. ArteriosclerThrombVascBiol, 2015, 35(1)∶7-8

miRNAs在牙周领域中的研究进展

Research Progress of MicroRNAs in Field of Periodontics

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