浓缩生长因子在上颌前牙区引导骨再生术中的临床应用

doi:10.13701/j.cnki.kqyxyj.2019.07.014

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (7): 676-680.DOI: 10.13701/j.cnki.kqyxyj.2019.07.014

浓缩生长因子在上颌前牙区引导骨再生术中的临床应用

于文凤^*, 赵世俊, 吕敏敏, 崔凤林, 康梅珍, 张志媛

沧州市人民医院口腔科河北沧州 061000

收稿日期:2018-11-16 出版日期:2019-07-25 发布日期:2019-07-24
通讯作者: 于文凤,E-mail:ywf320631002@163.com
作者简介:于文凤(1986~ ),女,河北保定人,硕士,主治医师,主要从事牙周及种植相关临床及科研工作

Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region

YU Wenfeng^*, ZHAO Shijun, LV Minmin, CUI Fenglin, KANG Meizhen, ZHANG Zhiyuan

Department of Stomatology, Cangzhou People’s Hospital, Cangzhou 061000, China.

Received:2018-11-16 Online:2019-07-25 Published:2019-07-24

摘要/Abstract

摘要： 目的:评价浓缩生长因子(concentrated growth factors,CGF)在上颌前牙区引导骨再生术中的临床疗效。方法:选取上颌单个前牙缺失伴唇侧牙槽骨缺损患者63例,随机分为实验组(32例)和对照组(31例)。实验组植入CGF＋Bio-Oss骨粉,表面覆盖CGF膜,对照组植入Bio-Oss骨粉,表面覆盖海奥生物膜。分别于术前、术后即刻和术后6个月拍摄锥形束CT(cone beam computed tomography,CBCT),并于术前、术后6个月测量术区角化龈宽度,比较两组手术前后CBCT和临床数据的变化。结果:实验组与对照组水平骨宽度术后较术前均有明显增加,差异有统计学意义(P＜0.01),实验组术后6个月水平骨增量显著高于对照组(P＜0.05),实验组的骨吸收率明显低于对照组,差异有统计学意义(P＜0.05)。实验组术后6个月角化龈宽度较术前显著增加,差异有统计学意义(P＜0.05),对照组无明显变化(P＞0.05)。结论:CGF应用于上颌前牙引导骨再生术中表现出了较强的软硬组织再生能力,是一种较理想的骨增量技术

关键词: 浓缩生长因子, 引导骨再生术, 软硬组织再生, 骨增量

Abstract: Objective: To evaluate the clinical effect of guided bone regeneration by using concentrated growth factors (CGF) in maxillary anterior region. Methods: 65 patients with single anterior tooth labial bone defect were enrolled and randomly divided into experimental group (32 cases) and control group (31 cases). The experimental group was treated with CGF combined with Bio-oss and covered with CGF membrane, and the control group was treated with Bio-oss and covered with biological membrane. Cone beam computed tomography (CBCT) was performed at baseline, immediate, and 6 months post-surgery, and the keratinized gingiva width was measured at baseline and 6 months post-surgery. The changes of clinical and CBCT data were compared between two groups. Results: There was a statistically significant increase in the horizontal bone width in both groups between baseline and post-surgery (P＜0.01) . Six months postoperatively, the gain of horizontal bone in the experimental groups was significantly higher than that in the control group (P＜0.05). The test group showed statistically significantly lower bone absorption rate than the control group (P＜0.05). Six months after operation, there was a statistically significant increase in the keratinized gingiva width in the experimental group compared with baseline (P＜0.05), however, there were no changes in the control group (P＞0.05). Conclusion: The application of CGF in guided bone regeneration of maxillary anterior region showed better effect on the regeneration of the soft and hard tissue.

Key words: concentrated growth factors, guided bone regeneration , regeneration of the soft and hard tissue, alveolar ridge augmentation

于文凤, 赵世俊, 吕敏敏, 崔凤林, 康梅珍, 张志媛. 浓缩生长因子在上颌前牙区引导骨再生术中的临床应用[J]. 口腔医学研究, 2019, 35(7): 676-680.

YU Wenfeng, ZHAO Shijun, LV Minmin, CUI Fenglin, KANG Meizhen, ZHANG Zhiyuan. Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region[J]. Journal of Oral Science Research, 2019, 35(7): 676-680.

参考文献

[1] 张璐,王频,郭玲,等.富自体浓缩生长因子纤维蛋白液在口腔骨缺损种植引导骨再生后的骨量变化[J].中国组织工程研究,2017,21(8):1186-1191.
[2] Rodella LF, Favero G, Boninsegna R, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction [J]. Microsc Res Tech,2011, 74(8): 772-777.
[3] Qin J, Wang L, Sun Y, et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo [J]. Int J Mol Med, 2016 ,37(2):493-500.
[4] Moussa M, El-Dahab OA, El Nahass H. Anterior maxilla augmentation using palatal bone block with platelet-rich fibrin: a controlled trial [J]. Int J Oral Maxillofac Implants, 2016, 31(3):708-715.
[5] 董衡,周娜,朱艳香,等.不同骨增量技术在上颌前牙区的临床对比研究[J].东南大学学报(医学版),2018,37(2):198-203.
[6] Clavijo-Alvarez JA, Vecchione L, DeCesare G, et al. Autologous bone grafting with adjunctive use of acellular dermal matrix for alveolar cleft defects: early outcomes [J]. Cleft Palate Craniofac J, 2010, 47(2):116-121.
[7] Wang HL, Boyapati L. "PASS" principles for predictable bone regeneration [J]. Implant Dent, 2006,15(1) : 8-17.
[8] Chiapasco M, Zaniboni M, Boisco M. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants [J]. Clin Oral Implants Res,2006,17:S136-S159.
[9] 孟焕新.临床牙周病学[M].第2版.北京大学医学出版社,2014:358-359.
[10] 柳宏志,李超 ,王天祥,等.CGF 联合骨代用品在即刻种植中修复种植体周围骨缺损的实验研究[J].口腔颌面外科杂志,2012,22(4):277-282.
[11] Masuki H, Okudera T, Watanebe T, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF) [J]. Int J Implant Dent,2016,2(1):19.
[12] Huang L, Zou R, He J,et al. Comparing osteogenic effects between concentrated growth factors and the acellular dermal matrix [J]. Braz Oral Res,2018,32:e29.
[13] 罗婷苑,张森林.浓缩生长因子促进骨再生的实验研究[J].口腔医学研究,2017,33(9): 954-957.
[14] Chenchev IL, Ivanova VV, Neychev DZ, et al. Application of platelet-rich fibrin and injectable platelet-rich fibrin in combination of bone substitute material for alveolar ridge augmentation -a case report [J]. Folia Med (Plovdiv), 2017, 59(3):362-366.
[15] Bozkurt DoganDogan?, Öngöz Dede F, Ball₁ U, et al. Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial [J]. J Clin Periodontol, 2015, 42(9): 868-875.

浓缩生长因子在上颌前牙区引导骨再生术中的临床应用

Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 13

编辑推荐

Metrics

[1]	刘春影, 周延民. 血小板浓缩物促进周围神经再生的研究进展[J]. 口腔医学研究, 2020, 36(6): 509-511.
[2]	乐柯, 董衡, 陈力, 杨光雯, 陈琳, 刘晖, 周娜, 牟永斌. 应用三维预成型钛网在上颌前牙区骨增量疗效的临床研究[J]. 口腔医学研究, 2020, 36(5): 481-485.
[3]	徐鸿玮, 储顺礼. 下颌后牙区水平向骨增量研究进展[J]. 口腔医学研究, 2020, 36(4): 321-323.
[4]	呙誉东, 周炼. 帐篷螺丝技术在上前牙区连续缺失种植修复中的疗效评价[J]. 口腔医学研究, 2020, 36(3): 298-301.
[5]	杨栋, 华先明, 李寒月, 董维理, 张晨, 曹正国. 一种牙周加速成骨正畸的改良术式和改良悬吊缝合法的设计、应用及初步评价[J]. 口腔医学研究, 2019, 35(9): 841-845.
[6]	李德超, 王心彧. 基于牵张成骨骨增量的种植前外科探讨[J]. 口腔医学研究, 2019, 35(4): 313-315.
[7]	季平, 杨生. 个性化钛网在口腔种植骨增量中的应用[J]. 口腔医学研究, 2019, 35(11): 1011-1015.
[8]	葛林虎, 方颖, 查骏, 李军, 万绵佳, 王丽萍. 浓缩生长因子促进大鼠种植体骨结合的实验研究[J]. 口腔医学研究, 2018, 34(7): 721-725.
[9]	王娜, 曲哲, 周宏志, 陈小冬. CGF在上颌窦外提升术中的临床应用效果评价[J]. 口腔医学研究, 2018, 34(2): 186-189.
[10]	罗婷苑，张森林. 浓缩生长因子促进骨再生的实验研究[J]. 口腔医学研究, 2017, 33(9): 954-957.
[11]	罗正文, 刘济远, 李佳, 潘剑. 引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的临床研究[J]. 口腔医学研究, 2017, 33(7): 782-786.
[12]	朱中焰, 张璐, 刘敏. 富自体浓缩生长因子纤维蛋白提取液对MC3T3-E1成骨细胞增殖与分化的影响[J]. 口腔医学研究, 2017, 33(11): 1147-1150.
[13]	付丽, 孙悦, 翟婧捷, 孙晓琳, 周延民. 3D打印及CGF在双侧下牙槽神经移位同期牙种植术中的应用[J]. 口腔医学研究, 2016, 32(10): 1003-1005.