高迁移率族蛋白1在颞下颌关节骨关节炎中的研究进展

doi:10.13701/j.cnki.kqyxyj.2020.12.005

摘要/Abstract

摘要： 高迁移率族蛋白1(high mobility group box-1 protein,HMGB1)是一种染色体结合蛋白,由激活细胞主动释放或坏死细胞被动释放,作为细胞因子参与炎症反应。颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)是临床常见疾病,迄今为止其发病机制尚未明确。有研究证实HMGB1在TMJOA组织中表达增高,本文以HMGB1的生物学特点为基础,对其在TMJOA中的研究进展作一综述,以期为治疗TMJOA提供新的思路。

关键词: 高迁移率族蛋白1, 颞下颌关节骨关节炎, 炎症, 信号通路

Abstract: High mobility group box-1 protein (HMGB1) is an architectural chromatin-binding protein that can be released actively by activated cells or passively by dying cells and can serve as a cytokine to drive the pathogenesis of inflammation. Temporomandibular joint osteoarthritis (TMJOA) is a common clinical disease, but so far, its pathogenesis is not yet clear. It has been confirmed that HMGB1 expression is increased in TMJOA tissues. Based on the biological characteristics of HMGB1, this article reviews the research progress of HMGB1 in TMJOA in order to provide new ideas for the treatment of TMJOA.

Key words: high mobility group box-1 protein, temporomandibular joint osteoarthritis, inflammation, pathway

胡智慧, 房维. 高迁移率族蛋白1在颞下颌关节骨关节炎中的研究进展[J]. 口腔医学研究, 2020, 36(12): 1099-1102.

HU Zhihui, FANG Wei. Role of HMGB1 in Temporomandibular Joint Osteoarthritis[J]. Journal of Oral Science Research, 2020, 36(12): 1099-1102.

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