铁代谢异常对牙周炎作用的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.03.004

摘要/Abstract

摘要： 牙周炎是目前导致我国成人失牙的首要原因,但由于其发病机制复杂,目前对牙周病的发病机制仍未明确。氧化应激为氧化剂和抗氧化剂分子之间的不平衡,局部和全身性氧化应激增加与牙周组织的炎症反应有关。铁是人体必需营养元素,是细胞中主要的催化剂,当细胞内的铁稳态被破坏能引发氧化应激。因此,铁代谢异常、氧化应激与牙周炎三者之间似乎存在着紧密联系。牙周组织发生炎症引发铁代谢异常,而铁代谢异常能够通过铁蛋白自噬引发氧化应激,进一步促进牙周炎的发生发展。并且铁代谢异常能够破坏骨稳态,加速牙槽骨吸收破坏。本文将在前人研究基础上,对铁代谢异常在牙周炎发病机制中的作用展开综述。

关键词: 牙周炎, 铁代谢, 活性氧, 铁死亡

Abstract: Currently, periodontitis is the leading reason of teeth lose in adults. However, we still know very little about the reason of periodontitis due to its complex pathogenesis. Oxidative stress is an imbalance between oxidant and antioxidant molecules. Increased local and systemic oxidative stress is associated with an inflammatory response in periodontal tissue. Iron is an essential nutrient for our bodies, and it also is the main catalyst in the cells. When iron homeostasis is disrupted in cells, it can trigger oxidative stress. Thus, there appears to be a strong link between abnormal iron metabolism, oxidative stress, and periodontitis. Inflammation of periodontal tissue can trigger abnormal iron metabolism, and abnormal iron metabolism can trigger oxidative stress by ferritinophagy, which can further contribute to the development of periodontitis. In addition, abnormal iron metabolism can disrupt bone homeostasis, and accelerate alveolar bone resorption. This paper reviews the role of abnormal iron metabolism in the pathogenesis of periodontitis.

Key words: periodontitis, iron metabolism, reactive oxygen species, ferroptosis

罗晓洁, 陈晓涛. 铁代谢异常对牙周炎作用的研究进展[J]. 口腔医学研究, 2023, 39(3): 202-205.

LUO Xiaojie, CHEN Xiaotao. Research Progress on Role of Abnormal Iron Metabolism in Periodontitis[J]. Journal of Oral Science Research, 2023, 39(3): 202-205.

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