鸢尾素对牙周组织修复和再生的调控作用及分子机制

doi:10.13701/j.cnki.kqyxyj.2025.05.002

口腔医学研究 ›› 2025, Vol. 41 ›› Issue (5): 369-372.DOI: 10.13701/j.cnki.kqyxyj.2025.05.002

鸢尾素对牙周组织修复和再生的调控作用及分子机制

杨雨欣, 马骞^*

南京医科大学附属口腔医院综合科,口腔疾病研究与防治国家级重点实验室培育建设点,江苏省口腔转化医学工程研究中心江苏南京 210029

收稿日期:2024-06-19 出版日期:2025-05-28 发布日期:2025-05-26
通讯作者: ^*马骞,E-mail:maqian@njmu.edu.cn
作者简介:杨雨欣(2000~ ),女,江苏淮安人,硕士在读,研究方向:纳米材料在骨再生中的应用。
基金资助:
国家自然科学基金(编号:81801029)江苏省卫生健康委科研项目面上项目(编号:M2022060)

Regulatory Effects and Molecular Mechanisms of Irisin on Periodontal Tissue Repair and Regeneration

YANG Yuxin, MA Qian^*

Department of General Dentistry, Affiliated Stomatological Hospital of Nanjing Medical University; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing 210029, China

Received:2024-06-19 Online:2025-05-28 Published:2025-05-26

摘要/Abstract

摘要： 鸢尾素(irisin)作为一种多肽激素,在减轻代谢综合征的炎症反应及治疗骨代谢相关疾病方面具有良好的作用。本文主要对鸢尾素的抗炎效能及其对骨代谢的影响与应用现状进行了综述,并总结了鸢尾素对牙周组织修复和再生的调控作用及分子机制,以探索其作为一种新型免疫制剂用于治疗牙周炎症性骨缺损的潜能。

关键词: 鸢尾素, 抗炎, 骨代谢, 牙周组织再生, 免疫制剂

Abstract: Irisin is a polypeptide hormone with a promising role in reducing the inflammatory response of metabolic syndrome and treating bone metabolism-related diseases. We reviewed the anti-inflammatory capacity of irisin and its influence on bone metabolism. What’s more, the regulatory effects and molecular mechanisms of irisin on periodontal tissue repair and regeneration were investigated, in order to explore the potential role of irisin as a novel immunological agent for the treatment of periodontal inflammatory bone defects.

Key words: irisin, anti-inflammatory, bone metabolism, periodontal tissue regeneration, immunological agents

杨雨欣, 马骞. 鸢尾素对牙周组织修复和再生的调控作用及分子机制[J]. 口腔医学研究, 2025, 41(5): 369-372.

YANG Yuxin, MA Qian. Regulatory Effects and Molecular Mechanisms of Irisin on Periodontal Tissue Repair and Regeneration[J]. Journal of Oral Science Research, 2025, 41(5): 369-372.

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鸢尾素对牙周组织修复和再生的调控作用及分子机制

Regulatory Effects and Molecular Mechanisms of Irisin on Periodontal Tissue Repair and Regeneration

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