间充质干细胞条件培养基中的分泌因子与牙周组织再生研究进展

doi:10.13701/j.cnki.kqyxyj.2021.07.004

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (7): 595-597.DOI: 10.13701/j.cnki.kqyxyj.2021.07.004

间充质干细胞条件培养基中的分泌因子与牙周组织再生研究进展

周雪纯, 孙新华^*

吉林大学口腔医院正畸科吉林长春 130021

收稿日期:2020-04-20 出版日期:2021-07-28 发布日期:2021-07-13
通讯作者: * 孙新华,E-mail:xinhuasun8@163.com
作者简介:周雪纯(1995~ ),女,辽宁大连人,硕士在读,主要从事正畸及牙周组织改建方面的研究。
基金资助:
国家自然科学基金面上项目(编号:81970946);吉林省财政厅科技项目(编号:jsz2018170-12);吉林省省级医药健康产业发展专项资金项目(编号:20170311032YY)

Research Progress of Secretion in Mesenchymal Stem Cell-derived Conditioned Medium with Periodontal Regeneration

ZHOU Xuechun, SUN Xinhua^*

Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2020-04-20 Online:2021-07-28 Published:2021-07-13

摘要/Abstract

摘要： 牙周炎是导致成年人牙齿缺失的最主要原因,理想的治疗目标是重建缺损的牙周组织,恢复牙齿的功能。近年来研究发现,干细胞诱导组织再生的能力来源于其旁分泌特性,其分泌的各种生物活性因子存在于间充质干细胞条件培养基(MSC-CM)中,发挥免疫调节和抗炎活性,调控细胞的迁移、增殖及分化,促进血管新生及牙周组织的修复。本文探讨了MSC-CM的基本概念及其应用于牙周组织再生方面的研究进展。

关键词: 间充质干细胞, 条件培养基, 牙周组织再生

Abstract: Periodontitis is the leading cause of tooth loss in adults. Rebuilding the defected periodontal tissue and restoring the tooth function are the ideal goal. In recent years, it has been found that the ability of stem cells to induce tissue regeneration is derived from paracrine characteristic. Various biological factors secreted by them exist in the conditioned medium (MSC-CM), exert immune regulation and anti-inflammatory function, regulate cell migration, proliferation, and differentiation, and promote angiogenesis and periodontal tissue repair. This article reviews the basic concepts of MSC-CM and its application for periodontal tissue regeneration.

Key words: mesenchymal stem cells, conditioned medium, periodontal tissue regeneration

周雪纯, 孙新华. 间充质干细胞条件培养基中的分泌因子与牙周组织再生研究进展[J]. 口腔医学研究, 2021, 37(7): 595-597.

ZHOU Xuechun, SUN Xinhua. Research Progress of Secretion in Mesenchymal Stem Cell-derived Conditioned Medium with Periodontal Regeneration[J]. Journal of Oral Science Research, 2021, 37(7): 595-597.

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间充质干细胞条件培养基中的分泌因子与牙周组织再生研究进展

Research Progress of Secretion in Mesenchymal Stem Cell-derived Conditioned Medium with Periodontal Regeneration

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