氨基酸代谢在头颈鳞状细胞癌中的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.09.002

摘要/Abstract

摘要： 头颈鳞状细胞癌(head and neck squamous cell carcinoma, HNSCC)是全球第六大常见的恶性肿瘤,具有侵袭性强、易转移以及预后差等特点。肿瘤细胞代谢重编程是HNSCC发生发展的关键特征之一,其中氨基酸代谢重编程作为肿瘤细胞重要的营养和能量来源,在促进HNSCC细胞快速增殖、适应肿瘤微环境等方面发挥着至关重要的作用。本综述旨在系统阐述氨基酸代谢重编程在HNSCC的研究进展,重点探讨其在疾病早期诊断、靶向治疗及预后判断中的潜在价值与应用前景,以期为提高HNSCC患者的生存质量及延长生存期提供有效策略。

关键词: 头颈鳞状细胞癌, 代谢重编程, 氨基酸代谢, 生物标志物

Abstract: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide, characterized by high invasiveness, easy metastasis, and poor prognosis. Tumor cell metabolic reprogramming is one of the key features in the occurrence and development of HNSCC. Among them, amino acid metabolic reprogramming, as an important source of nutrition and energy for tumor cells, plays a crucial role in promoting the rapid proliferation of HNSCC tumor cells and adapting to the tumor microenvironment. This review aims to systematically elaborate on the research progress of amino acid metabolic reprogramming in HNSCC, focusing on its potential value and application prospects in early diagnosis, targeted treatment, and prognosis assessment of the disease, with the aim of providing effective strategies to improve the survival quality and prolong the survival period of HNSCC patients.

Key words: head and neck squamous cell carcinoma, metabolic reprogramming, amino acid metabolism, biological markers

谭潇, 杨细虎. 氨基酸代谢在头颈鳞状细胞癌中的研究进展[J]. 口腔医学研究, 2026, 42(9): 740-745.

TAN Xiao, YANG Xihu. Research Progress on Amino Acid Metabolism in Head and Neck Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2026, 42(9): 740-745.

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