口腔医学研究 ›› 2017, Vol. 33 ›› Issue (11): 1230-1233.DOI: 10.13701/j.cnki.kqyxyj.2017.11.025

• 综述 • 上一篇    下一篇

纳米材料诱导的自噬与凋亡在抑制肿瘤生长和治疗中的作用及研究进展

王一博, 孙宾, 王丹丹, 唐琪, 孙宏晨*   

  1. 吉林大学口腔医院病理科 吉林 长春 130021
  • 收稿日期:2017-02-14 出版日期:2017-11-20 发布日期:2017-11-29
  • 通讯作者: 孙宏晨,E-mail: hcsun@jlu.edu.cn
  • 作者简介:王一博(1988~ ),男,吉林长春人,博士在读,主要从事口腔组织病理学研究。
  • 基金资助:
    国家自然科学基金(编号:81271111、8132010801)
    吉林省自然科学基金(编号: 30672338)

Effect and Progress of Autophagy Induced by Nanoparticles on Inhibition of Tumor Growth and Treatment

WANG Yi-bo, SUN Bing, WANG Dan-dan, TANG Qi, SUN Hong-chen*   

  1. Department of Pathology, Stomatology Hospital, Jinin University. Changchun 130021, China
  • Received:2017-02-14 Online:2017-11-20 Published:2017-11-29

摘要: 细胞自噬是细胞自身调节的重要生理反应,它与纳米颗粒有着密切的关联,近年来纳米与细胞自噬的研究成为生物医学领域的研究热点,有研究表明通过纳米颗粒有效的诱导在特定细胞中的自噬,可以加速病变细胞的死亡,对于治疗肿瘤和神经系统疾病等有着重要意义。本文介绍了细胞的自噬与凋亡过程、自噬与凋亡相互作用机制,阐述了不同类别的纳米颗粒诱导的自噬效应,并对纳米材料诱导自噬应用进行了展望,指出在研究中重点加强纳米颗粒与细胞自噬作用机理研究和纳米颗粒的可控性研究,更好地应用于生命科学。

关键词: 自噬, 凋亡, 纳米颗粒, 毒性

Abstract: Cell autophagy is an important physiological response of cell self-regulation. It is closely related to nanoparticles. In recent years, nanoparticle and autophagy have become a hotspot in biomedical research. The results show that the effective induction of autophagy by nanoparticles in the specific cells can accelerate the death of diseased cells, which has important significance for the treatment of tumors and nervous system diseases. In this paper, the progress of autophagy and apoptosis and the mechanism of autophagy and apoptosis were introduced. The autophagy induced by different nanoparticles was discussed. The application of nanomaterials in autophagy was also discussed. It is our duty to focus on the study of mechanism of nanoparticle and cell autophagy and the controllability of nanoparticles so as to better apply to life science and help to cure diseases.

Key words: Autophagy, Apoptosis, Nanoparticles, Toxicity

中图分类号: