口腔医学研究 ›› 2018, Vol. 34 ›› Issue (5): 474-476.DOI: 10.13701/j.cnki.kqyxyj.2018.05.004

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水凝胶的理化特性对干细胞行为的影响

杨雪, 高华丽, 张鲁鲁, 姜秋*, 金志恩, 王婷婷, 徐高祥   

  1. 吉林大学口腔医院儿童口腔科 吉林 长春 130021
  • 收稿日期:2017-03-27 出版日期:2018-05-28 发布日期:2018-05-29
  • 通讯作者: 姜秋,E-mail:jiangqiu1221@163.com
  • 作者简介:杨雪(1991~ ),女,山东临沂人,硕士,主要从事儿童口腔医学研究工作。
  • 基金资助:
    常见口腔疾病的诊断与治疗技术研发项目(编号:2014G075)

Influence of Physicochemical Property of Hydrogel on Stem Cell Behavior.

YANG Xue, GAO Hua-li, ZHANG Lu-lu, JIANG Qiu*, Jin Zhi-en, WANG Ting-ting, XU Gao-xiang   

  1. Department of Pediatric Dentistry, Stomatologic Hospital, Jilin University, Changchun 130021, China
  • Received:2017-03-27 Online:2018-05-28 Published:2018-05-29

摘要: 水凝胶是一种含有多种亲水基团,能在水中溶胀形成三维网络结构的高分子聚合物。能构建类似体内正常的细胞外微环境,为干细胞的粘附、增殖、分化和迁移提供良好的细胞外基质。然而水凝胶中干细胞的行为受到很多因素的影响,过去的研究主要集中在生物化学信号对干细胞分化的作用,近几年越来越多的研究者开始关注水凝胶材料本身的理化特性对干细胞行为的影响。因此本文主要就水凝胶的理化特性对干细胞行为的影响进行阐述。

关键词: 水凝胶, 化学特性, 物理特性, 干细胞行为

Abstract: Hydrogel is a kind of high molecular polymer which has a variety of hydrophilic groups and forms three-dimensional network structure. Hydrogel can construct extracellular microenvironment, and provide extracellular matrix for the adhesion, proliferation, differentiation and migration of stem cells. However, the behavior of the stem cells in hydrogel is influenced by many factors. Past researches mainly focused on the effect of biochemical signals on stems cells, however, more and more researchers begin to pay attention to the physicochemical properties of the hydrogel itself. In this paper, the effect of physicochemical properties of hydrogels on the behavior of stem cell was discussed.

Key words: Hydrogel, Chemical property, Physical property, Stem cell behavior