口腔医学研究

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (9): 974-978.DOI: 10.13701/j.cnki.kqyxyj.2018.09.013

• 口腔种植学研究 • 上一篇    下一篇

维药买朱尼对犬种植体周围炎骨改建的实验研究

吴佩佩,姑则丽努尔·阿布都克力木,朱亚玲,杨政尧,尼加提·吐尔逊*   

  1. 新疆医科大学第二附属医院口腔科 新疆 乌鲁木齐 830063
  • 收稿日期:2018-03-14 出版日期:2018-09-28 发布日期:2018-09-25
  • 作者简介:吴佩佩(1994~ ),女,浙江人,硕士在读,住院医师,主要从事口腔种植学研究。
  • 基金资助:
    新疆维吾尔自治区自然科学基金(编号:2016D01C192)

Experimental Study of Bone Remodelling after Maizhuni was Used to Treat Peri-implantitis in Dogs.

WU Pei-pei, Guzelinuer·Abudukelimu, ZHU Ya-ling, YANG Zheng-yao, Nijiati·Tuerxun*.   

  1. Department of Stomatology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830036, China.
  • Received:2018-03-14 Online:2018-09-28 Published:2018-09-25

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摘要： 目的: 研究维药买朱尼对犬种植体周围炎骨界面改建的影响。方法: 成功建立比格犬种植体周围炎模型后,随机分为3组,每组各3只,连续4周灌喂等量维药买朱尼、生理盐水、阿莫西林+甲硝唑,每日1次。4周后,监测3组探诊深度(PD)、种植体周围龈沟液(PISF),骨缺损量(骨缺损宽度DW、骨缺损深度DD、牙槽嵴水平BL)与组织学切片相结合观察种植体-骨界面改建情况。结果: 生理盐水组分别与其他两组相比较,PD、PISF量、DW、 DD、BL均有统计学意义(P＜0.05),抗身素组和维药买朱尼组相比较,PD、PISF量、DW、 DD、BL差异均无统计学意义。维药买朱尼组组织切片显示种植体颈部周围出现一定量的成骨细胞,骨髓区可见增生的新生骨细胞和骨小梁,生理盐水组种植体周围骨缺损较明显,骨缺损区可见纤维结缔组织。结论: 维药买朱尼治疗种植体周围炎能较好的改善软组织炎症,同时促进新骨形成,但骨缺损修复并未达到理想效果。

关键词: 种植体周围炎, 维药买朱尼, 骨改建, 种植体周围龈沟液

Abstract: Objective: To study the influence of maizhuni on implant-osseointegration interface remodeling of dog peri-implantitis. Methods: Peri-implantitis model of beagle dogs was successful established. Nine beagle dogs were randomly divided into three groups, which were given the same dose of Maizhuni, normal saline, and Amoxcillin capsules and M-etronidazole tablets. After a month,the implant-osseointegration interface remodeling was observed by monitoring the change of PD, PISF, bone defect(DW、DD and BL), and histology slices. Results: There were statistically significant differences in the index of PD, PISF, DW, DD, and BL content among three groups(P<0.05). There was no significant difference between the antibiotic and Maizhuni group in the index of PD, PISF, DW, DD, and BL. The histology slices of Maizhuni group showed that there had a certain amount of osteoblasts around the implant, and newly osteoblasts and bone trabecular were observed in the bone marrow area. Conclusion: Maizhuni can effectively improve the tissue inflammation status when treating peri-implantitis. However, the effect of bone defect repair is not ideal.

Key words: Peri-implantitis, Maizhuni , Bone remodelling, PISF