口腔医学研究 ›› 2017, Vol. 33 ›› Issue (11): 1234-1236.DOI: 10.13701/j.cnki.kqyxyj.2017.11.026

• 综述 • 上一篇    

白细胞介素-34与牙周炎、种植体周围炎的关系

吴立立, 史秋涛, 谷志远*   

  1. 浙江中医药大学口腔医学院 浙江 杭州 310053
  • 收稿日期:2016-03-25 出版日期:2017-11-20 发布日期:2017-11-29
  • 通讯作者: 谷志远,电话:0571-86633080
  • 作者简介:吴立立(1992~ ),女,浙江温州人,硕士在读,主要从事口腔种植临床研究。

Relationship between Interleukin-34 and Periodontitis and Peri-implantitis

WU Li-li,Shi Qiu-tao,GU Zhi-yuan*   

  1. School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • Received:2016-03-25 Online:2017-11-20 Published:2017-11-29

摘要: 牙周炎和种植体周围炎可使牙周组织破坏,支持骨丧失,导致牙脱落和种植术失败。IL-34具有免疫抑制特性,与M-CSF有共同的受体--M-CSFR,并且能与RANKL协同促进破骨细胞形成,可能在牙周炎和种植体周围炎的发生发展中有重要作用。本文将对IL-34引起骨吸收机制及免疫调节功能进行概述,有助于更深入的了解牙周炎和种植体周围炎的致病机理,为临床防治提供新的方向。

关键词: 白细胞介素-34, 牙周炎, 种植体周围炎

Abstract: Periodontitis and peri-implantitis influence the periodontal tissues, and result in the supporting bone loss and even tooth and implant loss. Interleukin-34 is a tolerogenic cytokine sharing the same receptor--M-CSFR with M-CSF, and is a stimulator of osteoclasts differentiation that exerts synergistic effects with RANKL and might perform an important function in the occurrence and development of periodontitis and peri-implantitis. In this paper, the mechanism of bone resorption and immunoregulatory function of interleukin-34 is summarized, which is greatly significant for understanding the pathogenic mechanism and clinical treatment of periodontitis and peri-implantitis.

Key words: Interleukin-34, Periodontitis, Peri-implantitis

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