微小RNA-155调控骨代谢的研究进展

doi:10.13701/j.cnki.kqyxyj.2020.11.002

摘要/Abstract

摘要： 正常的骨代谢有赖于骨形成与骨吸收之间的平衡,这一平衡的打破会导致多种骨相关疾病。微小RNA(microRNAs,miRNA) 作为转录后调控因子,参与了骨代谢的调控,其异常表达也会引起骨组织病理性改变。它作为治疗骨相关疾病的潜在靶点,在未来临床治疗中具有相当的应用前景。miR-155作为目前研究较多的miRNAs 之一,其在调控骨代谢方面的作用也逐渐被阐明,本文就miR-155调控骨代谢的具体机制做一综述。

关键词: 微小RNA-155, 骨代谢, 成骨分化, 破骨分化

Abstract: Normal bone metabolism depends on a delicate balance between bone formation and bone resorption, which leads to a variety of bone-related diseases after break. As post-transcriptional factors, microRNAs are involved in the control of bone metabolism. Abnormalities in the function of microRNAs can also cause pathological changes in osseous tissue. As a potential target for the treatment of bone-related diseases, it has considerable application prospects in future clinical treatment. MicroRNA-155 is one of the most studied microRNAs, and its role in regulating bone metabolism has gradually been illustrated. This article reviews the concrete mechanism of microRNA-155 in regulating bone metabolism.

Key words: microRNA-155, bone metabolism, osteoblastic differentiation, osteoclastic differentiation

张成晓雪, 赵青. 微小RNA-155调控骨代谢的研究进展[J]. 口腔医学研究, 2020, 36(11): 992-995.

ZHANG Chengxiaoxue, ZHAO Qing. Research Progress of MicroRNA-155 in Regulating Bone Metabolism[J]. Journal of Oral Science Research, 2020, 36(11): 992-995.

参考文献

[1] Fang S,Deng Y,Gu P,et al.MicroRNAs regulate bone development and regeneration [J]. Int J Mol Sci,2015,16(4):8227-8253.
[2] Kang H, Hata A.The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis [J]. BMB Rep,2015,48:319-323.
[3] Steven R,Nicole I.microRNA regulation of skeletal development [J]. Curr Osteoporos Rep,2017,15(4):353-366.
[4] Anneke B, Jean H.MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post-transcriptional gene regulation [J].Bioessays,2014,36(6):617-626.
[5] Zhang J, Zhou W, Liu Y, et al. Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5′UTR of RUNX3 [J]. Oncol Lett,2018,15:7215-7220.
[6] Jacob O,Heyam H,Chun P,et al. Overview of microRNA biogenesis,mechanisms of actions,and circulation [J]. Front Endocrinol (Lausanne),2018, 9:402.
[7] Rupal O, Raj N, Rajan K, et al. Emerging role of circulating microRNA in the diagnosis of human infectious diseases [J]. J Cell Physiol,2019,234(2):1030-1043.
[8] Robyn B,Stephen F,Orina B. miR-155 in the resolution of atherosclerosis [J]. Front Pharmacol, 2019,(10):463.
[9] Hanne D, Pernille S,Julie S, et al. miR-155 as a biomarker in B-cell malignancies [J].Biomed Res Int,2016,2016:9513037.
[10] Ugo T,Elvira P,Germana C, et al. miR-146 and miR-155: two key modulators of immune response and tumor development [J]. Non-coding RNA,2017,(3):22.
[11] Takanori E,Ken W, Emilio S, et al. OstemiR:A novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells [J]. PLoS One,2015,8(3): e58796.
[12] Yang L,Ge D,Cao X,et al.MiR-214 attenuates osteogenic differentiation of mesenchymal stem cells via targeting FGFR1 [J]. Cell Physiol Biochem,2016,38(2):809-820.
[13] Binbin L.MicroRNA Regulation in Osteogenic and Adipogenic Differentiation of Bone Mesenchymal Stem Cells and its Application in Bone Regeneration [J]. Curr Stem Cell Res Ther,2018,13 (1):26-30.
[14] Wei F,Liu D,Feng C, et al. MicroRNA-21 mediates stretch- induced osteogenic differentiation in human periodontal ligament stem cells [J]. Stem Cells Dev,2015,24(3):312-319.
[15] Li Y, Fan L, Hu J, et al. MiR-26a rescues bone regeneration deficiency of mesenchymal stem cells derived from osteoporotic mice [J]. Mol Ther,2015,23(8):1349-57.
[16] Cong H, Junnan G, Siwen J. MicroRNAs in regulation of osteogenic differentiation of mesenchymal stem cells [J]. Cell Tissue Res,2017,368:229-238.
[17] Mengrui W, Guiqian C, Yiping L, et al. TGF-β and BMP Signaling in Osteoblast, Skeletal Development, and Bone Formation, Homeostasis and Disease [J]. Bone Res,2016,4:16009.
[18] Valerie S, Laura W, Vicki R. BMP Signalling in Skeletal Development, Disease and Repair [J]. Nat Rev Endocrinol,2016,12(4):203-21.
[19] Cao Y, LV Q, LV C. MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II [J].Int J Mol Med,2015,36(3):760-766.
[20] Gu Y, Ma L, Song L, et al. miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression [J]. Biomed Res Int,2017:1893520.
[21] Wu T, Xie M, Wang X, et al. miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression [J]. Bone,2012,51:498-505.
[22] Liu H, Zhong L,Yuan T, et al. MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway [J]. Int J Mol Med,2018,41(6):3379-93.
[23] Liu H,Yan H,Yan J, et al. Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System [J]. PLoS ONE,2016,11:e0165063.
[24] Oki Y,Doi K,Makihara Y, et al. Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model [J]. J Oral Sci,2016,58:241-246.
[25] Laxman N,Rubin C,Mallmin H,et al. Second generation sequencing of microRNA in Human Bone Cells treated with Parathyroid Hormone or Dexamethasone [J]. Bone,2016,84:181-188.
[26] Han H,Ju F,Geng S. In vivo and in vitro effects of PTH1-34 on osteogenic and adipogenic differentiation of human bone marrow-derived mesenchymal stem cells through regulating microRNA-155 [J]. J Cell Biochem,2018,119(4):3220-35.
[27] Skårn M,Namløs HM,Noordhuis P, et al. Adipocyte Differentiation of Human Bone Marrow-Derived Stromal Cells Is Modulated by MicroRNA-155, MicroRNA-221, and MicroRNA-222 [J]. Stem Cells Dev,2012,21(6):873-883.
[28] Liu S,Yang Y,Wu J. TNFα-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors [J]. Biochem Biophys Res Commun,2011,28;414(3):618-624.
[29] Niroshani S,Neil A. Osteoclast Function and Bone-Resorbing Activity: An Overview [J]. iochem Biophys Res Commun,2016,476(3):115-120.
[30] Mann M,Barad O,Agami R,et al. miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate [J]. Proc Natl Acad Sci USA,2010,107:15804-9.
[31] Zhang J, Zhao H,Chen J, et al. Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF [J]. FEBS Lett,2012,586:3255-62.
[32] Zhao H,Zhang J,Shao H,et al. Transforming Growth Factor β1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression [J]. Mol Cells,2017,40(3):211-221.
[33] Sul OJ, Sung YB, Rajasekaran M, et al. MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 uponlipopolysaccharide stimulation [J]. Bone,2018,116(11):279-289.
[34] Josef S, Daniel A, Iain B. Rheumatoid Arthritis [J]. Lancet,2016,388 (10055): 2023-38.
[35] Lin CS, An FH,Hong J, et al. Role of microRNA-155 in Rheumatoid Arthritist [J]. J Rheum Dis, 2017,20(11):1631-37.
[36] S Blüml,M Bonelli, B Niederreiter, et al. Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice [J]. Arthritis Rheum,2011,63(5):1281-88.
[37] Saintpastou TC, Gasque P. Bone responses in health and infectious diseases: A focus on osteoblasts [J]. J Infect,2017,75(4):281-292.
[38] Lin N, Chen C, Kagwiria R, et al. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss [J]. Ann Rheum Dis,2016,75(6):1203-10.
[39] J Lv, L Yang, R Guo, et al. Ox-LDL-induced MicroRNA-155 promotes autophagy in human endothelial cells via repressing the Rheb/mTOR pathway [J]. Cell Physiol Biochem,2017,43(4):1436-48.
[40] Wu X, Hu K, Huang W. Commentary: Association between alendronate use and hip fracture risk in older patients using oral prednisolone [J]. Front Aging Neurosci,2017,9:357.
[41] Liu A, Li Y, Wang Y, et al. Exogenous parathy- roid hormone-related peptide promotes fracture healing in Lepr (-/-) mice [J]. Calcif Tissue Int,2015,97:581-591.
[42] Mao Z, Zhu Y, Hao W, et al. MicroRNA-155 inhibition up-regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate-treated osteoporotic mice [J]. IUBMB Life,2019,18(7):1-13.