原发性腮腺平滑肌肉瘤临床病理分析

doi:10.13701/j.cnki.kqyxyj.2021.06.009

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (6): 519-522.DOI: 10.13701/j.cnki.kqyxyj.2021.06.009

原发性腮腺平滑肌肉瘤临床病理分析

余方^1,2*, 陈琼荣^1,2, 向远航^1,2, 徐剑^1,2

1.武汉大学中南医院病理科湖北武汉 430071;
2.武汉大学病理中心湖北武汉 430071

收稿日期:2020-11-23 出版日期:2021-06-28 发布日期:2021-06-17
通讯作者: *余方,E-mail:63595362@qq.com
作者简介:余方(1982~ ),女,湖北人,主治医师,博士,研究方向:临床病理诊断。

Clinicopathological Analysis of Primary Leiomyosarcoma of Parotid Gland

YU Fang^1,2*, CHEN Qiongrong^1,2, XIANG Yuanhang^1,2, XU Jian^1,2

1. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
2. Center for Pathology and Molecular Diagnostics, Wuhan University, Wuhan 430071, China

Received:2020-11-23 Online:2021-06-28 Published:2021-06-17

摘要/Abstract

摘要： 目的:探讨原发性腮腺平滑肌肉瘤(leiomyosarcoma,LMS)的临床病理特征及其鉴别诊断要点。方法:对两例原发性腮腺LMS进行临床病理观察和免疫组化结果分析,并对该疾病的相关文献进行复习。结果:2例男性患者腮腺区肿块,镜下肿瘤细胞均呈长梭形平行或交织条束状排列,侵及周围组织;免疫组化结果显示肿瘤细胞表达SMA、Caldesmon。两例患者均接受手术及术后放射治疗,随访两年未见复发及远处转移。结论:原发性腮腺LMS是颌面部罕见恶性肿瘤,术前诊断较为困难,免疫组织化学有助于该疾病的诊断。

关键词: 腮腺, 平滑肌肉瘤, 免疫组织化学

Abstract: Objective: To investigate the clinicopathological features and differential diagnosis of primary leiomyosarcoma (LMS) of parotid gland. Methods: Two cases of primary parotid LMS were observed clinicopathologically and analyzed immunohistochemically, and the related literatures were reviewed. Results: Two male patients presented with parotid masses. Pathologic findings revealed that the sarcoma was composed of tumor cells arranged in a long spindle shape, parallel or interwoven bundles, and invaded the surrounding tissues. The immunohistochemical results showed that the tumor cells expressed SMA and Caldesmon. Two patients received surgery and radiotherapy and were followed up for two years without recurrence or distant metastasis. Conclusion: Primary parotid gland LMS was a rare malignant tumor in the maxillofacial region, which was difficult to be diagnosed preoperatively. Immunohistochemistry was helpful to the diagnosis of this disease.

Key words: parotid gland, leiomyosarcoma, immunohistochemistry

余方, 陈琼荣, 向远航, 徐剑. 原发性腮腺平滑肌肉瘤临床病理分析[J]. 口腔医学研究, 2021, 37(6): 519-522.

YU Fang, CHEN Qiongrong, XIANG Yuanhang, XU Jian. Clinicopathological Analysis of Primary Leiomyosarcoma of Parotid Gland[J]. Journal of Oral Science Research, 2021, 37(6): 519-522.

参考文献

[1] Cockerill CC, Daram S, El-Naggar AK, et al. Primary sarcomas of the salivary glands: case series and literature review [J]. Head Neck, 2013, 35(11): 1551-1557.
[2] Luna MA, Tortoledo ME, Ordonez NG, et al. Primary sarcomas of the major salivary glands [J]. Arch Otolaryngol Head Neck Surg, 1991, 117(3): 302-306.
[3] Auclair PL, Langloss JM, Weiss SW, et al. Sarcomas and sarcomatoid neoplasms of the major salivary gland regions. A clinicopathologic and immunohistochemical study of 67 cases and review of the literature [J]. Cancer, 1986, 58(6): 1305-1315.
[4] Kang J, Levinson JA, Hitti IF, Leiomyosarcoma of the parotid gland: a case report and review of the literature [J]. Head Neck, 1999, 21(2): 168-171.
[5] Yue LE, Qazi M, Kiplagat K, et al. A rare primary leiomyosarcoma of the parotid gland: A case report and literature review [J]. Am J Otolaryngol, 2018, 39(3): 345-348.
[6] Sandhyamani S, Mahapatra AK, and Kapur BM. Leiomyosarcoma of the parotid gland [J]. Aust N Z J Surg, 1983, 53(2): 179-181.
[7] Oncel S, Doganay M, Ozer A, et al. Leiomyosarcoma of the parotid gland [J]. J Laryngol Otol, 1996, 110(4): 401-403.
[8] Maheshwari GK, Baboo HA, Patel MH, et al. Leiomyosarcoma of the parotid gland metastatic to the scalp: A rare primary location with unusual metastatic lesion [J]. Turkish Journal of Cancer, 2003, 33(4): 191-194.
[9] Krüger S, Sommer K. Leiomyosarcoma of the parotid gland: a case report [J]. Eur Arch Otorhinolaryngol, 2006, 263(10): 951-954.
[10] Sethi A, Mrig S, Sethi D, et al. Parotid gland leiomyosarcoma in a child: an extremely unusual neoplasm [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006, 102(1): 82-84.
[11] 向国林,龙星,韩前超.涎腺平滑肌肉瘤一例[J].中华耳鼻喉头颈外科杂志,2012,47(1): 72-73.
[12] Coulter M, Liu J, Marzouk M. Leiomyosarcoma Ex pleomorphic adenoma of the parotid gland: A case report and literature review [J]. Case Rep Otolaryngol, 2016, 2016: 9795785.
[13] Ambekar A, Soman CS, Bhatia S. Leiomyosarcoma of parotid gland [J]. Indian J Pathol Microbiol, 2017, 60(4): 624-626.
[14] 史晓兰,左淑英,宋艳芳,等.肉瘤样变异型涎腺导管癌1例报道[J].诊断病理学杂志,2020,27(7):508-510.
[15] 王坚,朱雄增.软组织肿瘤病理学[M] .第2版.北京:人民卫生出版社,2017.
[16] 郭倩倩,牛丽娟,彭琴,等.颈部滑膜肉瘤侵及甲状腺一例[J].中华肿瘤杂志,2019,41(9): 716-718.
[17] 白永,尹迎春,韩学锋,等.头颈部低度恶性肌纤维母细胞肉瘤二例分析[J].山东大学耳鼻喉眼学报,2018,32(4): 58-61.
[18] 张辰宇,温伟生,陶冶.腮腺区炎性肌纤维母细胞瘤6例临床分析[J].口腔医学研究,2016,32(6): 648-651.

原发性腮腺平滑肌肉瘤临床病理分析

Clinicopathological Analysis of Primary Leiomyosarcoma of Parotid Gland

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李昌忆, 郑凌艳. 腮腺炎症疾病的细菌学研究进展[J]. 口腔医学研究, 2020, 36(11): 996-999.
[2]	陶博强, 刘映坤, 李雨阳, 闵锋鹤, 刘慧敏, 杨之婧, 刘炜炜. 胸锁乳突肌瓣与口腔修复膜在腮腺良性肿瘤术后应用的比较分析[J]. 口腔医学研究, 2020, 36(11): 1036-1039.
[3]	洪小伟, 孙国文, 王志勇, 朱锋, 李威. 耳前扩展切口在副腮腺肿瘤切除术中的应用[J]. 口腔医学研究, 2020, 36(10): 912-914.
[4]	刘坤, 闫广鹏, 陈俊文, 高鹏, 李军. 小肠黏膜下层预防腮腺良性肿瘤术后味觉出汗综合征的疗效观察[J]. 口腔医学研究, 2019, 35(8): 772-775.
[5]	高旭,周阳,李琛,薛晓寒,魏秀峰. Eya4在口腔鳞状细胞癌中的表达及其意义[J]. 口腔医学研究, 2019, 35(6): 555-558.
[6]	王亚敏, 孟文霞, 周震, 郭薇, 谢宝仪. 口腔扁平苔藓组织中α-平滑肌肌动蛋白的表达及临床意义[J]. 口腔医学研究, 2019, 35(4): 393-396.
[7]	覃珊珊,王代友,眭斌,张岩,孙喆. 狗肝菜多糖对辐射损伤后大鼠腮腺中血管内皮生长因子的表达变化和意义[J]. 口腔医学研究, 2019, 35(2): 125-128.
[8]	张凯, 李春明. 腮腺肿瘤术后面部畸形与Frey综合征综合防治的研究进展[J]. 口腔医学研究, 2019, 35(1): 20-22.
[9]	唐学敏, 孙长华, 朱玉红, 王晶, 杨勇, 丁长玲, 左金华. 水通道蛋白5和细胞程序性死亡分子5在大鼠腮腺主导管结扎再通后表达的实验研究[J]. 口腔医学研究, 2018, 34(7): 774-779.
[10]	马丽娟, 杨兰, 王志强, 董仙, 黄英博. 腮腺区毛母质细胞瘤1例[J]. 口腔医学研究, 2018, 34(7): 798-800.
[11]	刘冲, 李吉辰, 赛音乌力吉, 朴松林, 曹博, 赵大勇. IL-24在口腔鳞状细胞癌中的表达及其临床意义[J]. 口腔医学研究, 2018, 34(6): 632-635.
[12]	赵厚亮, 王文涛, 王伟, 徐凯. CT纹理分析在腮腺多形性腺瘤与腺淋巴瘤鉴别诊断中的价值[J]. 口腔医学研究, 2018, 34(10): 1127-1131.
[13]	陈栋, 鲁方丽, 李晓聪, 王莹莹, 李强. SSUH2在小鼠牙胚发育中的时空表达[J]. 口腔医学研究, 2018, 34(1): 14-17.
[14]	高润涛, 耿雪霏. 8例腮腺恶性淋巴瘤诊疗体会[J]. 口腔医学研究, 2017, 33(8): 870-873.
[15]	王琛, 冯雪峰, 王如. 腮腺皮脂腺癌1例[J]. 口腔医学研究, 2017, 33(7): 790-791.