口腔上皮整合素的研究进展

doi:10.11839/kqyxzh.2016.01.025

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (1): 96-99.DOI: 10.11839/kqyxzh.2016.01.025

口腔上皮整合素的研究进展

张天首,张一迪,孟帅岑,王鹤澄,文超举,周延民^*

吉林大学口腔医学院种植中心吉林长春 130021

收稿日期:2015-04-20 出版日期:2016-01-28 发布日期:2016-03-21
通讯作者: 周延民,E-mail:zhouym@jlu.edu.cn
作者简介:张天首(1988~),男,长春人,博士,主要从事口腔种植方面研究。
基金资助:
国家自然科学基金(编号:81200809)
高等学校博士学科点专项科研基金(编号:20120061110077)
吉林省科技发展计划项目(编号:20130522037JH)

Research Progress of Integrins in Oral Epithelium.

ZHANG Tian-shou, ZHANG Yi-di, MENG Shuai-chen, WANG He-cheng, Wen Chao-ju, Zhou Yan-min.

Department of Dental Implantology, School and Hospital of Stomatology, Jilin University. Changchun 130021, China

Received:2015-04-20 Online:2016-01-28 Published:2016-03-21

摘要/Abstract

摘要： 整合素(Integrin)是一种跨膜蛋白,可以介导细胞-细胞或细胞-细胞外基质(extracellular matrix,ECM)的粘附。整合素通过与ECM配体结合,从而活化特定的信号转导途径,介导细胞的黏附、迁移和增生等多种生物学功能。在口腔中,上皮细胞对ECM的粘附力更是维持口腔健康和种植体稳定的关键。在本文中,我们将讨论口腔内上皮整合素的结构、信号途径和对ECM作用,并对整合素介导口腔内结合上皮粘附的机制的最新研究进展进行综述。

关键词: 整合素, 角化细胞, 细胞外基质, 半桥粒

Abstract: Integrin is a kind of transmembrane protein, which mediates cell-cell or cell-extracellular matrix (ECM) adhesion. Integrin combined with ECM can active transduction pathways, mediate cell adhesion, migration and proliferation, and determine the cell biological functions. In the oral cavity, the adhesion of epithelial cells on the ECM keeps oral healthy and implant stability. In this review, the effect of oral epithelium integrin structure on the ECM is discussed, and the progress of mechanism of integrin mediated oral epithelial adhesion is reviewed.

中图分类号:

R782.02

张天首,张一迪,孟帅岑,王鹤澄,文超举,周延民. 口腔上皮整合素的研究进展[J]. 口腔医学研究, 2016, 32(1): 96-99.

ZHANG Tian-shou, ZHANG Yi-di, MENG Shuai-chen, WANG He-cheng, Wen Chao-ju, Zhou Yan-min.. Research Progress of Integrins in Oral Epithelium.[J]. Journal of Oral Science Research, 2016, 32(1): 96-99.

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口腔上皮整合素的研究进展

Research Progress of Integrins in Oral Epithelium.

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