口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (11): 1148-1150.

• 临床研究论著 • 上一篇    下一篇

舍格伦综合征患者唇腺中CCL28的表达和分布研究

刘雪1,柳忠豪1,卢志山1*,高月华2   

  1. 1. 烟台市口腔医院 山东 烟台 264008;
    2. 滨州医学院口腔医学院 山东 烟台 264003
  • 收稿日期:2015-04-08 出版日期:2015-11-28 发布日期:2016-03-21
  • 通讯作者: 卢志山,E-mail:sdkqliux@163.com
  • 作者简介:刘雪(1984~),女,山东烟台人,主治医师,硕士,主要从事口腔免疫相关研究
  • 基金资助:
    烟台市科学技术发展计划项目(编号:2010151)

Expression and Distribution of CCL28 in Labial Glands of Sjgren Disease

LIU Xue1, LIU Zhong-hao1, LU Zhi-shan1, GAO Yue-hua2.   

  1. 1. Yantai Stomatological Hospital, Yantai 264008, China; 2. Hospital of Stomatology, Binzhou Medical University, Yantai, 264003, China
  • Received:2015-04-08 Online:2015-11-28 Published:2016-03-21

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摘要： 目的:研究舍格伦综合征患者唇腺中粘膜相关上皮趋化因子CCL28的表达和分布情况。方法:收集35名患者的唇腺组织分别进行半定量RT-PCR及免疫组化。结果:患者的唇腺组织中表达CCL28 mRNA,但表达量较健康组织少。未被破坏的腺上皮细胞、导管上皮细胞及腺管内黏液可见棕色染色。结论:舍格伦综合征患者唇腺中 仍有CCL28的表达及分泌,为我们日后探寻该类患者的龋病及口腔感染的预防奠定了基础。

Abstract: Objective: To detect the expression and distribution of CCL28 in human labial glands of Sjogren disease. Methods: All labial gland samples came from 35 patients who were diagnosed as Sjogren disease. CCL28 mRNA was detected by semiquantitative RT-PCR and CCL28 protein was detected by immunohistochemistry. Results: CCL28 mRNA was expressed in the labial glands of Sjogren disease, which was lower than that in the control. Positive staining of CCL28 was identified in the glandular epithelial cells, duct epithelial cells and mucus. Conclusion: CCL28 expressed and distributed in the labial glands of Sjogren disease. This would help doctors prevent tooth decay and oral infections in these patients.

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