口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (1): 1-3.

• 基础研究论著 •    下一篇

拔牙窝填塞Bio-oss人工骨对延期种植骨结合影响的组织学观察

邱泽文1,刘慧颖2,仲维剑2,郑辉2,马国武2*   

  1. 1. 大连医科大学动物实验中心 辽宁 大连 116044;
    2. 大连医科大学口腔医学院
  • 收稿日期:2014-06-26 出版日期:2015-01-28 发布日期:2016-04-29
  • 通讯作者: 马国武,电话:0411-86110397
  • 作者简介:邱泽文(1967~ ),男,辽宁省人,硕士,主要从事实验动物模型建立方面的研究。
  • 基金资助:
    国家自然科学基金课题(编号:81000669);辽宁省自然科学基金(编号:201102045)

Histological Observation for Osseointegration of Delayed Implantation with Bio-Oss Following Tooth Extraction.

Qiu Ze-wen, LIU Hui-ying, ZHONG Wei-jian, et al   

  1. Dalian Medical University, Dalian 116044
  • Received:2014-06-26 Online:2015-01-28 Published:2016-04-29

PDF (PC)

238

摘要： 目的:评价拔牙后牙槽窝内填塞Bio-oss人工骨对延期种植骨结合的影响,为临床提供实验依据。方法:全麻下拔除6只杂种犬双侧下颌第三、四前磨牙,随机选取两个拔牙窝作为实验组,牙槽窝内填塞Bio-oss人工骨粉并覆盖钛膜;另外两个拔牙窝不作任何处理作为对照组。术后3个在植入种植体,Golden's三色法观察种植体周围骨结合。结果:实验组及对照组种植体周围新骨均生成良好,实验组3个月可见Bio-oss颗粒;种植体植入术后3个月实验组的骨-种植体接触率及种植体周围骨面积均显著高于对照组,差异有统计学意义(P＜0.05)。种植体植入术后6个月实验组的骨-种植体接触率及种植体周围骨面积略高于对照组,但差异无统计学意义。结论:拔牙窝内填塞Bio-oss人工骨有利于延期种植骨结合。

关键词: Bio-oss, 种植体, 延期种植, 骨结合

Abstract: Objective: To evaluate the influence on the osseointegration of delayed implantation of dental implant with Bio-Oss artificial bone following tooth extraction. Methods: The bilateral 3rd and 4th mandibular premolars of 6 adult, healthy, male and female dogs were extracted. We randomly selected 2 extraction sockets in each dog to be filled with Bio-Oss (the experimental group); the other 2 extraction sockets which were not treated served as the control group. Dental implants were inserted into the alveolar bone of the experimental group and the control group 3 months after Bio-Oss placement. The osteogenic activity in the bone around the implants was assessed by evaluating the histological morphology and estimating histomorphometric parameters 3 and 6 months after delayed implantation. Results: After the 3 months, Goldner's trichrome staining analysis showed that the bone-implant contact rate and mineralized bone area around the implant were significantly higher in the experimental group (75.98%±8.97% and 69.52%±9.63%, respectively) than those in the control group (56.13%±8.18% and 52.82%±7.25%, respectively, P<0.05). However, no significant difference was found between the 2 groups after 6 months. Conclusion: These data indicate that alveolar ridge preservation by using Bio-Oss placement can promote osseointegration of delayed implantation, and may be a promising option for clinical use.

Key words: Bio-Oss Implant, Delayed implantation, Osseointegration

中图分类号: