新型负载生物离子种植体涂层的抗菌学研究

doi:10.13701/j.cnki.kqyxyj.2020.03.014

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (3): 247-250.DOI: 10.13701/j.cnki.kqyxyj.2020.03.014

新型负载生物离子种植体涂层的抗菌学研究

吴千驹^1,2*, 张志升^1,2, 林志明^1,2, 金地^1,2, 张怡^1,2, 骆碧珠^1,2

1. 厦门医学院附属口腔医院厦门市口腔医院修复科福建厦门 361008;
2. 厦门市口腔疾病诊疗重点实验室福建厦门 361008

收稿日期:2019-05-05 出版日期:2020-05-15 发布日期:2020-05-15
通讯作者: 吴千驹,E-mail:qianjuwu@163.com
作者简介:吴千驹(1989~),男,福建厦门人,博士在读,主治医师,主要从事口腔种植体表面改性以及其临床应用研究。
基金资助:
厦门市科技局科技惠民计划(编号:3502Z20184063)

Antimicrobial Effect of A Novel Titanium Implant Incorporated with Bioactive Ion

WU Qianju^1,2*, ZHANG Zhisheng^1,2, LIN Zhiming^1,2, JIN Di^1,2, ZHANG Yi ^1,2, LUO Bizhu^1,2

1. Department of Prosthodontics, Stomatological Hospital of Xiamen Medical College, Xiamen 361008, China;
2. Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Xiamen Medical College, Xiamen 361008, China

Received:2019-05-05 Online:2020-05-15 Published:2020-05-15

摘要/Abstract

摘要： 目的：将具有抗菌学效应的生物离子合成至种植体表面化学组分当中并研究其体外抗菌学性能。方法：采用电化学方法将Cu离子导入种植表面从而达到修饰表面化学组分的目的,同时检测样品表面离子的释放情况;并针对所制备的材料进行如下生物学检测:(1)激光共聚焦检查测材料表面细菌状态;(2)计算抗菌学效率。结果：材料学检测证实随着时间的推移,表面涂层能够以持续、缓慢的速率释放Cu等离子。抗菌学实验检测显示出负载离子活性涂层表面细菌存活率大大降低,对其抗菌效率进行分析得到了一致的结果。结论：通过电化学法能够在种植体表面成功制备出负载生物离子缓释涂层,且该涂层具有良好的抗菌能力,为将来种植体周围炎的解决提供新的思路。

关键词: 种植体, 生物离子, 体外释放, 抗菌学

Abstract: Objective: To evaluate the antimicrobial effect in vitro of implant coating by introducing antimicrobial ion. Methods: A novel coating was prepared on dental implant surface via electrochemistry approach by introducing antimicrobial ion to recombine chemical composition, and concentrations of ions being released were measured. The biological performances were systematically explored as follows:(1) Survival situation of bacteria cultured on specimens was observed by CLSM; (2) Antimicrobial rate was calculated. Results: It was found that this functionalized implant controlled copper ions release in a sustained pattern. Additionally, it was capable of reducing viability of oral pathogens effectively, displaying its excellent antibacterial property. Conclusion: It was suggested that implant coatings incorporated with antimicrobial element by electrochemistry approach for sustained release pattern and superior antimicrobial activity could be achieved.

Key words: implants, bioactive ion, controlled-release, antimicrobial performance

吴千驹, 张志升, 林志明, 金地, 张怡, 骆碧珠. 新型负载生物离子种植体涂层的抗菌学研究[J]. 口腔医学研究, 2020, 36(3): 247-250.

WU Qianju, ZHANG Zhisheng, LIN Zhiming, JIN Di, ZHANG Yi , LUO Bizhu. Antimicrobial Effect of A Novel Titanium Implant Incorporated with Bioactive Ion[J]. Journal of Oral Science Research, 2020, 36(3): 247-250.

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新型负载生物离子种植体涂层的抗菌学研究

Antimicrobial Effect of A Novel Titanium Implant Incorporated with Bioactive Ion

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