牙周致病微生物与药物性牙龈肥大的关系

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (4): 370-372.

牙周致病微生物与药物性牙龈肥大的关系

刘海杰¹, 潘亚萍^1,2*

1. 中国医科大学口腔医学院牙周科辽宁沈阳 110002;
2. 辽宁省口腔医学研究所牙周病学研究室

收稿日期:2014-08-25 出版日期:2015-04-28 发布日期:2016-04-29
通讯作者: 潘亚萍,E-mail:yppan@mail.cmu.edu.cn
作者简介:刘海杰(1983~ ),女,辽宁省葫芦岛市人,硕士,医师,现工作于中国医科大学附属第四医院口腔科,主要从事牙周病的临床治疗与研究。
基金资助:
国家自然科学基金项目(编号:81271153)

Relationship between Periodontal Pathogens and Drug-induced Gingival Enlargement.

LIU Hai-jie, PAN Ya-ping

School of Stomatology,China Medical University, Shenyang 110001

Received:2014-08-25 Online:2015-04-28 Published:2016-04-29

摘要/Abstract

摘要： 目的:探讨菌斑微生物在硝苯地平诱导的药物性牙龈肥大中的作用。方法:采用Real-time PCR技术对服用硝苯地平后出现药物性牙龈肥大的高血压患者(A组,23例)、服用硝苯地平后未出现药物性牙龈肥大的高血压患者(B组,23例)、慢性牙周炎者(C组,23例)龈下菌斑内牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、中间普氏菌(Prevotella intermedia,Pi)、齿垢密螺旋体(Treponema denticola,Td)和福赛坦氏菌(Tannerella forsythia,Tf)进行相对定量检测,比较3组患者龈下菌斑中4种牙周致病微生物相对含量的差异。结果:Pg、Td、Tf、Pi在A组明显高于B组,两者之间有统计学差异(P<0.05), A组与C组比较无统计学差异。结论:菌斑微生物在硝苯地平诱导的药物性牙龈肥大中起着重要作用。

关键词: 药物性牙龈肥大, 牙周致病菌, 硝苯地平

Abstract: Objective: To investigate the role of periodontal pathogens in nifedipine-induced gingival enlargement. Methods: The differences of relative quantification of periodontal pathogens including porphyromonas gingivalis (Pg), prevotella intermedia (Pi), treponema denticola (Td), tannerella forsythia (Tf) were tested in hypertension patients with nifedipine-induced gingival enlargement (Group A, 23cases) , hypertension patients taking nifedipine without nifedipine-induced gingival enlargement (Group B, 23cases) , patients with chronic periodontitis (Group C, 23cases) using real-time PCR. Results: The relative quantification of Pg、Td、Tf and Pi between Group A and Group B had statistically difference (P<0.05), Group A was higher than Group B, but had no statistical difference between Group A and Group C. Conclusion: Plaque microorganisms play a very important role in nifedipine-induced gingival enlargement.

Key words: Drug-induced gingival enlargement, Periodontal pathogens , Nifedipine

中图分类号:

R781.4

刘海杰, 潘亚萍. 牙周致病微生物与药物性牙龈肥大的关系[J]. 口腔医学研究, 2015, 31(4): 370-372.

LIU Hai-jie, PAN Ya-ping. Relationship between Periodontal Pathogens and Drug-induced Gingival Enlargement.[J]. Journal of Oral Science Research, 2015, 31(4): 370-372.

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