纳米支架及合成技术在神经组织再生的应用

doi:10.13701/j.cnki.kqyxyj.2017.04.028

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (4): 459-462.DOI: 10.13701/j.cnki.kqyxyj.2017.04.028

• 综述 • 上一篇

纳米支架及合成技术在神经组织再生的应用

张震^1,3, 李莹¹, 耿亚伟², 徐东阳³, 李德志³, 张斌^{1,3, *}

1. 哈尔滨医科大学硬组织发育和再生研究所黑龙江哈尔滨 150001;
2. 第二附属医院口腔修复科黑龙江哈尔滨 150001;
3. 第二附属医院口腔颌面外科黑龙江哈尔滨 150001

收稿日期:2015-11-17 出版日期:2017-04-20 发布日期:2017-04-24
通讯作者: 张斌,E-mail:zhb19622003@yahoo.com
作者简介:张震(1990~ ),男,山东济宁人,硕士在读,主要从事组织工程学研究。

Nanoscaffolds and Nanofabrication Techniques for Neural Tissue Regeneration.

ZHANG Zhen^1,3, LI Ying¹, GENG Ya-wei², XU Dong-yang³, LI De-zhi³ ZHANG Bin^1,3*

1. Institute of Hard Tissue Development and Regeneration, Harbin Medical University. Harbin 15001, China;
2. Department of Prosthodontics, the Second Affiliated Hospital of Harbin Medical University. Harbin 15001, China;
3. Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 15001, China.

Received:2015-11-17 Online:2017-04-20 Published:2017-04-24

摘要/Abstract

摘要： 神经系统受损常见于不同背景、年龄的人群。当前有许多促神经组织再生的方法,其中组织工程方法应用前景最为良好。采用组织工程技术合成的功能性神经支架,可用于代替、修复受损神经。组织工程技术合成的神经支架具有高度仿生性,且重建神经功能的成功率较高。尤其是纳米技术的应用,在很大程度上促进了神经组织工程技术的发展创新和成功运用。本文重点讨论采用纳米生物材料和生物活性物质以及静电纺丝技术、新出现的3D打印技术和自组装技术合成具有三维结构的纳米纤维神经支架来促进神经组织修复与再生研究进展。

Abstract: Tissue engineering is the promising avenue to improve neural regeneration. Functional nerve scaffolds synthesized by tissue engineering techniques present substitutes for implantation and rehabilitation of injured nerves. The scaffolds have a high degree of biomimetic and a superior rate of successful neural function construction. Particularly, the application of nanotechnology has greatly promoted the development of neural tissue engineering technology and the successful application of the technology. In this paper, we focus on the development of nano-scaffold and nanotechonlogy on the nerve tissue repair and regeneration of the nerve tissue, which is synthesized by the nano material and the biological active material, the electrospinning technology, the new 3D printing technology, and the self assembly technology.

Key words: Neural tissue-engineering , Nanotechnology, Scaffold , Electrospinning, 3D printingSelf-assembly

中图分类号:

R318

张震, 李莹, 耿亚伟, 徐东阳, 李德志, 张斌. 纳米支架及合成技术在神经组织再生的应用[J]. 口腔医学研究, 2017, 33(4): 459-462.

ZHANG Zhen, LI Ying, GENG Ya-wei, XU Dong-yang, LI De-zhi ZHANG Bin. Nanoscaffolds and Nanofabrication Techniques for Neural Tissue Regeneration.[J]. Journal of Oral Science Research, 2017, 33(4): 459-462.

参考文献

[1] Assmann U, Szentivanyi A, Stark Y, et al. Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration [J]. J Mater Sci, 2010, 21(7)∶2115-2124
[2] Ma Z, Kotaki M, Inai R, Ramakrishna S. Potential of nanofiber matrix as tissue-engineering scaffolds [J]. Tissue Eng, 2005, 11(1-2)∶101-109
[3] Xie J, Willerth SM, Li X et al. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages [J]. Biomaterials, 2009, 30(3)∶354-362
[4] Christopherson GT, Song H, Mao HQ. The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation [J]. Biomaterials, 2009, 30(4)∶556-564
[5] Moon S, Haeggstrom E, Khademhosseini A, et al. Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets [J]. Tissue Eng Part C Methods, 2010, 16(1)∶157-166
[6] Hur J, Seo M. Optical proximity corrections for digital micromirror device-based maskless lithography [J]. J Opt Soc Korea, 2012, 16(3)∶221-227
[7] Suri S, Han L-H, Zhang W, et al. Solid freeform fabrication of designer scaffolds of hyaluronic acid for nerve tissue engineering [J]. Biomed Microdevices, 2011, 13(6)∶983-993
[8] Ferris CJ, Gilmore KJ, Beirne S, et al. Bio-ink for on-demand printing of living cells [J]. Biomater Sci, 2013, 1(2)∶224-230
[9] Owens CM, Marga F, Forgacs G, et al. Biofabrication and testing of a fully cellular nerve graft [J]. Biofabrication, 2013, 5(4)∶380-387
[10] Ozbolat IT, Yu Y. Bioprinting toward organ fabrication:challenges and future trends [J]. IEEE Trans Biomed Eng, 2013, 60(3)∶691-699
[11] An J, Chua CK, Yu T, et al. Advanced nanobiomaterial strategies for the development of organized tissue engineering constructs [J]. Nanomedicine, 2013, 8(4)∶591-602
[12] Melchels FPW, Domingos MaN, Klein TJ, et al.Additive manufacturing of tissues and organs [J]. Prog Polym Sci, 2012, 37(8)∶1079-1104
[13] Huebsch N, Mooney DJ. Inspiration and application in the evolution of biomaterials [J]. Nature, 2009, 462(7272)∶426-432
[14] Gelain F, Bottai D, Vescovi A, et al. Designer selfassembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures [J]. PLoS ONE, 2006, 1(2)∶e119-
[15] Zhang L, Webster TJ. Nanotechnology and nanomaterials: promises for improved tissue regeneration [J]. Nano Today, 2009, 4(1)∶66-80
[16] Seidlits SK, Lee JY, Schmidt CE. Nanostructured scaffolds for neural applications [J]. Nanomedicine, 2008, 3(2)∶183-199
[17] Cellot G, Scaini D, Gelain F, et al. Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts [J]. Nat Nanotechnol., 2009, 4(2)∶126-133
[18] Zhang JC, Liu DD, Zhou GQ, et al. Application of nanomaterials in tissue eng [J]. Prog Chem, 2010, 22(11)∶2232-2237
[19] Sherrell PC, Thompson BC, Wassei JK, et al. Maintaining cytocompatibility of biopolymers through a grapheme layer for electrical stimulation of nerve cells [J]. Adv Funct Mater, 2013, 24(6)∶769-776
[20] Li N, Zhang X, Song Q, et al. The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates [J]. Biomaterials, 2011, 32(35)∶9374-9382
[21] Gu X, Ding F, Yang Y, et al. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration [J]. Prog Neurobiol, 2011, 93(2)∶204-230

纳米支架及合成技术在神经组织再生的应用

Nanoscaffolds and Nanofabrication Techniques for Neural Tissue Regeneration.

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