巨噬细胞在材料诱导成骨中作用的研究进展

doi:10.13701/j.cnki.kqyxyj.2017.10.026

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (10): 1123-1126.DOI: 10.13701/j.cnki.kqyxyj.2017.10.026

巨噬细胞在材料诱导成骨中作用的研究进展

李明政^1,2，肖宇¹，吴珍珍¹，包崇云^1,2*

1. 四川大学口腔疾病研究国家重点实验室四川成都 610041；
2. 四川大学华西口腔医学院口腔颌面外科四川成都 610041

收稿日期:2016-09-01 出版日期:2017-10-20 发布日期:2017-10-24
通讯作者: 包崇云,E-mail: cybao9933@sina.com
作者简介:李明政(1989~ ),男,山东人,硕士在读,主要从事骨诱导生物材料在颌骨缺损方面的应用及机制探索研究。
基金资助:
国家自然科学基金资助项目(编号:81371181)

Research Progress on the Role of Macrophage during Biomaterials Induced Bone Information

LI Ming-Zheng^1,2, XIAO Yu¹, WU Zhen-zhen¹, BAO Chong-Yun^1,2*

1. State Key Laboratory of Oral Diseases, Sichuan University. Chengdu 610041, China;
2. Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University. Chengdu 610041, China.

Received:2016-09-01 Online:2017-10-20 Published:2017-10-24

摘要/Abstract

摘要： 目的:对巨噬细胞在材料诱导骨形成中作用的相关研究进行综述。方法:广泛查阅近年来国内外相关文献进行总结。结果:巨噬细胞在促进成骨方面发挥着关键作用,生物材料的颗粒大小及表面形貌均可通过影响巨噬细胞的形态及功能进而影响在骨诱导过程中的作用。结论:掌握巨噬细胞在骨诱导过程中的作用及机制,对于准确评估生物材料是否具有骨诱导性及优化骨替代材料具有重要意义。

关键词: 巨噬细胞, 骨诱导, 骨形成, 生物材料, 成骨细胞

Abstract: Objective: To review the research progress on the role of macrophage during osteoinduction. Methods: The literatures concerning this aspect were extensively reviewed and analyzed. Result: On one hand, macrophage has a key impact on bone formation. On the other hand, the surface topography and particle size of biomaterials can affect the function of macrophage in promoting bone formation. Conclusion: Understanding the role and mechanism of macrophage during osteoinction is important to accurate evaluate the osteoinduction of biomaterials. What's more, it is important to improve the property of biomaterials.

Key words: Macrophage, Osteoinduction , Bone formation, Biomaterials, Osteoblast

中图分类号:

R318

李明政，肖宇，吴珍珍，包崇云. 巨噬细胞在材料诱导成骨中作用的研究进展[J]. 口腔医学研究, 2017, 33(10): 1123-1126.

LI Ming-Zheng, XIAO Yu, WU Zhen-zhen, BAO Chong-Yun. Research Progress on the Role of Macrophage during Biomaterials Induced Bone Information[J]. Journal of Oral Science Research, 2017, 33(10): 1123-1126.

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巨噬细胞在材料诱导成骨中作用的研究进展

Research Progress on the Role of Macrophage during Biomaterials Induced Bone Information

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