长链非编码RNAs与细胞分化

doi:10.13701/j.cnki.kqyxyj.2017.10.027

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (10): 1127-1130.DOI: 10.13701/j.cnki.kqyxyj.2017.10.027

• 综述 • 上一篇

长链非编码RNAs与细胞分化

吴文桢^1,2，王开娟³，王家伟^1*

1. 武汉大学口腔医学院湖北武汉 430079；
2. 兰州市口腔医院甘肃兰州 730000；
3. 兰州大学口腔医学院甘肃兰州 730000

收稿日期:2016-06-17 出版日期:2017-10-20 发布日期:2017-10-24
通讯作者: 王家伟,Email: wangjwei@hotmail.com
作者简介:吴文桢(1978~ ),男,甘肃兰州人,学士,主治医师,主要从事口腔修复的临床诊疗与科研工作。
基金资助:
兰州市人才创新创业项目(编号:2014-RC-79)兰州市卫生科技发展计划(编号:LZWSKY2014-2-15)“中央高校基本科研业务费专项资金”重点项目(编号:lzujbky-2016-k17)

Review on Correlation Between Long Non-coding RNAs and Cell Differentiation

WU Wen-zhen^1,2, WANG Kai-juan³, WANG Jia-wei^1*

1. School of Stomatology, Wuhan University, Wuhan 430079, China;
2. Lanzhou Stomatological Hospital, Lanzhou 730000, China;
3. School of Stomatology, Lanzhou University, Lanzhou 730000, China.

Received:2016-06-17 Online:2017-10-20 Published:2017-10-24

摘要/Abstract

摘要： 随着遗传学及生物信息学技术的快速发展,曾被称为转录"噪音"的长链非编码RNAs(Long non-coding RNAs,LncRNAs)越来越受到学者们的广泛关注。研究发现,LncRNAs在生物体各种生命活动中具有重要的调节作用,其对基因表达的调控作用已成为生命科学研究的热点问题。研究证实,LncRNAs通过信号分子、诱饵分子、引导分子、支架分子等方式,对遗传、转录及转录后等进行水平调控,如细胞分化等生物学过程。本文就LncRNAs与细胞分化的关系作一综述,包括LncRNAs与多能干细胞多能性的维持及分化、与神经细胞分化、与肌肉分化、与成骨细胞分化的机制,以及LncRNAs与口腔鳞状细胞癌的关系。

关键词: 长链非编码RNAs, 细胞分化, 机制

Abstract: With the rapid development of genetics and bioinformatics technology, the long non-coding RNA (LncRNA) which once was considered as the transcription "noise", is now attracted more and more attention. It has been confirmed that LncRNA plays an important regulation role in almost all kinds of life activities, especially in the process of regulating gene expression by signaling molecules, decoy molecules, lead molecules, and scaffold molecular, etc, which has been one of the most hottest issues in life science. It is also known that LncRNAs performs their biological functions at different levels, including cell differentiation. This paper is to discuss the correlation between LncRNAs and cell differentiation, which includes LncRNAs with pluripotent stem cells who maintain their pluripotency and differentiation, LncRNAs with nerve cell differentiation, LncRNAs with muscles differentiation, and LncRNAs with osteoblast differentiation.

Key words: LncRNAs , Cell differentiation, Mechanism

中图分类号:

R780.1

吴文桢，王开娟，王家伟. 长链非编码RNAs与细胞分化[J]. 口腔医学研究, 2017, 33(10): 1127-1130.

WU Wen-zhen, WANG Kai-juan, WANG Jia-wei. Review on Correlation Between Long Non-coding RNAs and Cell Differentiation[J]. Journal of Oral Science Research, 2017, 33(10): 1127-1130.

参考文献

[1] Hacisuleyman E, Shukla CJ, Weiner CL, et al. Function and evolution of local repeats in the Firre locus [J]. Nat Commun, 2016,7∶11021
[2] Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development [J]. Nat Rev Genet, 2014, 15(1)∶7-21
[3] Morlando M, Ballarino M, Fatica A, et al. The role of long noncoding RNAs in the epigenetic control of gene expression [J]. ChemMedChem, 2014, 9(3)∶505-510
[4] Postepska-Igielska A1, Giwojna A1, Gasri-Plotnitsky L, et al. LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure [J]. Mol Cell, 2015, 60(4)∶626-636
[5] Kotake Y, Naemura M, Murasaki C. Regulation of cell proliferation and apoptosis by long noncoding RNA, ANRIL and PANDA [J]. Seikagaku, 2015, 87(2)∶230-233
[6] Yoon JH, Kim J, Gorospe M. Long noncoding RNA turnover [J]. Biochimie, 2015, 117∶15-21
[7] Lai F, Orom UA, Cesaroni M, et al. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription [J]. Nature, 2013, 494(7438)∶497-501
[8] Chen L, Wang W, Cao L, et al. Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia [J]. Mol Cells, 2016
[9] Sugimoto C, Fujita H, Wakao H. Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases [J]. World J Stem Cells, 8(4)∶158-169
[10] Nishino K, Umezawa A. DNA methylation dynamics in human induced pluripotent stem cells [J]. Hum Cell. 2016
[11] Rosa A, Ballarino M. Long Noncoding RNA Regulation of Pluripotency [J]. Stem Cells Int, 2016, 2016∶1797692
[12] Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development [J]. Nat Rev Genet, 2014, 15(1)∶7-21
[13] Morlando M, Ballarino M, Fatica A, et al. The role of long noncoding RNAs in the epigenetic control of gene expression [J]. ChemMedChem, 2014, 9(3)∶505-510
[14] Khalil AM, Guttman M, Huarte M, et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression [J]. Proc Natl Acad Sci USA, 2009, 106(28)∶11667-11672
[15] Guttman M, Donaghey J, Carey BW, et al. lincRNAs act in the circuitry controlling pluripotency and differentiation [J]. Nature, 2011, 477(7364)∶295-300
[16] Ji P, Manupipatpong S, Xie N, et al. Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming [J]. Stem Cells Int, 2016, 2016∶8415010
[17] Xu L, Tan YY, Ding JQ, et al. The iPS technique provides hope for Parkinson's disease treatment [J]. Stem Cell Rev, 2010, 6(3)∶398-404
[18] Kim JB, Sebastiano V, Wu G, et al. Oct4-Induced Pluripotency in Adult Neural Stem Cells [J]. Cell, 2009, 136(3)∶411-419
[19] Francescatto M, Vitezic M, Heutink P, et al. Brain-specific noncoding RNAs are likely to originate in repeats and may play a role in up-regulating genes in cis [J]. Int J Biochem Cell Biol, 2014, 54∶331-337
[20] Lv J, Liu H, Huang Z, et al. Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features [J]. Nucleic Acids Res, 2013, 41(22)∶10044-10061
[21] Aprea J, Prenninger S, Dori M, et al. Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment [J]. EMBO J, 2013, 32(24)∶3145-3160
[22] Saghaeian Jazi M, Samaei NM, Ghanei M, et al. Identification of new SOX2OT transcript variants highly expressed in human cancer cell lines and down regulated in stem cell differentiation [J]. Mol Biol Rep, 2016, 43(2)∶65-72
[23] Ng SY, Bogu GK, Soh BS, et al. The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis [J]. Molecular Cell, 2013, 51(3)∶349-359
[24] Shang YC, Wang SH, Xiong F, et al.Activation of Wnt3a signaling promotes myogenic differentiation of mesenchymal stem cells in mdx mice [J]. Acta Pharmacol Sin, 2016
[25] Gong C, Li Z, Ramanujan K, et al. A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation [J]. Dev Cell, 2015, 34(2)∶181-191
[26] Guo-qiang Wang, Yu Wang, Yan Xiong, et al. Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a [J]. Sci Rep, 2016, 6∶21865
[27] Cesana M, Cacchiarelli D, Legnini I, et al. A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA [J]. Cell, 2011, 147(2)∶358-369
[28] Kallen AN, Zhou XB, Xu J, et al. The imprinted H19 LncRNA antagonizes let-7 microRNAs [J]. Molecular Cell, 2013,52(1)∶101-112
[29] Song WQ, Gu WQ, Qian YB, et al.Identification of long non-coding RNA involved in osteogenic differentiation from mesenchymal stem cells using RNA-Seq data [J]. Genet Mol Res, 2015, 14(4)∶18268-18279
[30] Jia Q, Jiang W, Ni L. Down-regulated non-coding RNA (LncRNA-ANCR) promotes osteogenic differentiation of periodontal ligament stem cells [J]. Archives of Oral Biology, 2015, 60(2)∶234-241
[31] Sannigrahi MK, Sharma R, Panda NK, et al. Role of Non-coding RNAs in Head and Neck Squamous Cell Carcinoma: a narrative review [J]. Oral Dis, 2017 Sep 21. doi: 10.1111/odi.12782. [Epub ahead of print]
[32] Gibb EA, Enfield KS, Stewart GL, et al. Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions [J]. Oral Oncol, 2011, 47(11)∶1055-1061
[33] Chang SM, Hu WW. Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis [J]. J Cell Physiol, 2017 Sep 19. doi: 10.1002/jcp.26185. [Epub ahead of print]
[34] Shih JW, Chiang WF, Wu ATH, et al. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression [J]. Nat Commun, 2017, 8∶15874
[35] Wu Y, Zhang L, Zhang L, et al. Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma [J]. Int J Oncol, 2015, 46(6)∶2586-2594

长链非编码RNAs与细胞分化

Review on Correlation Between Long Non-coding RNAs and Cell Differentiation

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