维甲酸抗肿瘤活性及其作用机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2018.04.005

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (4): 356-358.DOI: 10.13701/j.cnki.kqyxyj.2018.04.005

维甲酸抗肿瘤活性及其作用机制的研究进展

孙宾^1,2, 孙宏晨^2*

1. 吉林大学口腔医学院口腔颌面外科吉林长春 130021;
2. 吉林大学牙发育与颌骨重塑吉林省重点实验室吉林长春 130021

收稿日期:2016-10-26 出版日期:2018-04-28 发布日期:2018-04-25
通讯作者: 孙宏晨,E-mail:hcsun@jlu.edu.cn
作者简介:孙宾(1982~ ),男,甘肃天水人,博士在读,主要从事口腔颌面部肿瘤诊断和治疗的相关研究。
基金资助:
国家自然科学基金面上项目(编号:81271111)

Research Progress on Anti-tumor Activity and Functionary Mechanism of Retinoic Acid

SUN Bin^1,2, SUN Hong-chen^2*

1. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130021, China;
2. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun 130021, China.

Received:2016-10-26 Online:2018-04-28 Published:2018-04-25

摘要/Abstract

摘要： 在正常组织中维甲酸参与调控多种组织干细胞的分化,在人体发育过程中具有重要的作用。并且研究已经证实对于多种肿瘤,维甲酸同样具有抑制肿瘤生长和诱导肿瘤干细胞分化的作用。本文通过结合现有文献,拟阐述维甲酸抗肿瘤活性及其发挥作用的机制,以期为将来的研究提供理论基础。

关键词: 维甲酸, 作用机制, 肿瘤

Abstract: In normal tissues, retinoic acid is involved in the regulation of differentiation of various tissue stem cells and plays an important role in human development. Moreover, it has been proved that retinoic acid can inhibit tumor growth and induce differentiation of tumor stem cells. The purpose of this review is to present the literature on the antitumor activity of retinoic acid and its mechanisms, which provides the basis for future research.

Key words: Retinoic acid, Functionary mechanism, Cancer

孙宾, 孙宏晨. 维甲酸抗肿瘤活性及其作用机制的研究进展[J]. 口腔医学研究, 2018, 34(4): 356-358.

SUN Bin, SUN Hong-chen. Research Progress on Anti-tumor Activity and Functionary Mechanism of Retinoic Acid[J]. Journal of Oral Science Research, 2018, 34(4): 356-358.

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维甲酸抗肿瘤活性及其作用机制的研究进展

Research Progress on Anti-tumor Activity and Functionary Mechanism of Retinoic Acid

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