Preparation and Bacteriostasis Effects of Poly(VBA-co-VBTAC)/XF-70

doi:10.13701/j.cnki.kqyxyj.2020.03.016

Abstract

Abstract: Objective: To evaluate the physicochemical properties of poly (4-vinyl benzoic acid co (ar-vinyl benzyl) trimethylammonium chloride poly (VBA-co-VBTAC)/XF-70 nanofibers, and to explore their inhibitory effects on the formation of bacterial biofilms. Methods: Poly (VBA-co-VBTAC) nanofibers were prepared and compared with Poly (VBA-co-VBTAC)/XF-70. The morphology of the nanofibers was observed by SEM. The release curves of Staphylococcus aureus and Porphyromonas gingivalis biofilms were measured by high-performance liquid chromatography (HPLC), and the in vitro models of Staphylococcus aureus and Porphyromonas gingivalis biofilms were established. Bacterial inhibition tests were carried out on 1.00 mg/L XF-70 and Poly (VBA-co-VBTAC)/XF-70 with the same content of XF-70, respectively. Results: The release of XF-70 within 300 minutes was nearly 80%. The biofilm formation (absorbance value) of the two bacteria decreased significantly, and the bacteriostasis effect of Poly (VBA-co-VBTAC)/XF-70 was significantly better than that of XF-70 group (P<0.05). Conclusion: Poly (VBA-co-VBTAC)/XF-70 has a good short-term release curve, which can improve the inhibition of XF-70 on the formation of biofilm of Staphylococcus aureus and Porphyromonas gingivalis.

Key words: poly(VBA-co-VBTAC), XF-70, nanofibers, bacteriostasis

WANG Yansong, LIU Jianlin, CHEN Xiaoxia. Preparation and Bacteriostasis Effects of Poly(VBA-co-VBTAC)/XF-70[J]. Journal of Oral Science Research, 2020, 36(3): 255-258.

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