Expression of DKK-1/BMP-2 in the Healing of Mandibular High Condylar Fracture

doi:10.13701/j.cnki.kqyxyj.2020.08.011

Abstract

Abstract: Objective: To explore the expression of Dickkopf-1 (DKK-1) and bone morphogenetic protein-2(BMP-2) in the healing of mandibular high condylar fracture. Methods: The experimental animal model of high condylar fracture of mandible was established in 24 rabbits. The rabbits were randomly divided into control group and experimental group. The condylar periosteum soft tissue was removed in the experimental group but remained in the control group. The animals were killed separately in 1, 2, 3, and 4 weeks after operation, and the histomorphological changes of new bone was observed by HE staining, and the expression of BMP-2 and DKK-1 in new bone tissue was detected by immunohistochemistry. Results: With the extension of fixation time, the healing speed and quality of the fracture area in the control group were better than that in the experimental group. The expression of BMP-2 in the control group was higher than that in the experimental group, and the expression of DKK-1 in the control group was lower than that in the experimental group. Conclusion: The delayed bone healing after free reduction and fixation of high condylar fracture of mandible may relate to insufficient blood supply and increased expression of DKK-1.

Key words: mandibular condyle, fracture healing, bone morphogenetic protein, Dickkopf-1

WANG Dongxiang, WANG Guangsu, TANG Zhenglong, CHEN Youli, GAO Qiong, AN Ning. Expression of DKK-1/BMP-2 in the Healing of Mandibular High Condylar Fracture[J]. Journal of Oral Science Research, 2020, 36(8): 748-752.

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