Research Progress of PKM2 in Odontogenic Keratocysts

doi:10.13701/j.cnki.kqyxyj.2024.11.003

Abstract

Abstract: The odontogenic keratocyst (OKC) is a developmental cyst that has high potential for invasiveness, easy recurrence, and multiple occurrences. Its energy metabolism pathway is mainly glycolysis. Pyruvate kinase M2 (PKM2) is a key driving factor of glycolysis and plays an important role in regulating the tumor metabolic microenvironment. The traditional Chinese medicine (TCM) has a long history of treating tumors with its unique theory of "steady-state" effect on the tumor immune microenvironment. This review will delve into the regulation of PKM2 in respect of odontogenic keratocysts, aiming to provide new ideas for the clinical treatment of OKC with traditional Chinese medicine.

Key words: odontogenic keratocyst, pyruvate kinase M2, glycolysis, tumor, traditional Chinese medicine, microenvironment

WANG Haojun, ZHA Guangyu. Research Progress of PKM2 in Odontogenic Keratocysts[J]. Journal of Oral Science Research, 2024, 40(11): 956-959.

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