Journal of Oral Science Research ›› 2024, Vol. 40 ›› Issue (12): 1121-1124.DOI: 10.13701/j.cnki.kqyxyj.2024.12.018

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Oral Lichenoid Drug Reactions and Gingival Bleeding Induced by Atezolizumab and Bevacizumab: A Case Report

LI Jiaqi, LI Xinlei, ZHOU Gang*   

  1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral Medicine, School and Hospital of Stomatology ,Wuhan University ,Wuhan 430079,China
  • Received:2024-12-01 Online:2024-12-28 Published:2024-12-23

Abstract: Oral lichenoid drug reactions (OLDR) refer to lichenoid manifestation of the oral mucosa induced by specific drugs in individuals with allergic predispositions. There are numerous types of drugs that can trigger OLDR, but reports on oral lichenoid drug reactions induced by immunotherapy are rare. This manuscript reports a case of OLDR and gingival bleeding induced by atezolizumab and bevacizumab combination anticancer therapy, and explores its clinical features, as well as the diagnostic and treatment approaches. The aim of this case is to provide valuable insights for the clinical management of this disease.

Key words: oral lichenoid drug reactions, atezolizumab, bevacizumab, immune-related adverse events