Research Progress of ATFs Family in Oral Pathologies and Odontogenesis

doi:10.13701/j.cnki.kqyxyj.2025.11.003

Abstract

Abstract: Oral pathologies are one of the most prevalent diseases globally, severely affecting oral health, function, and aesthetics. The activating transcription factors (ATFs) family belongs to the bZIP transcription factor superfamily, including ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7, and is involved in processes such as cell proliferation, migration, invasion, apoptosis, and differentiation. In recent years, studies have highlighted the functional significance of ATFs in oral development, tissue regeneration, inflammation, and tumorigenesis. However, comprehensive reviews summarizing recent advances on the ATFs family in oral pathologies remain scarce, and the molecular mechanisms governing their regulatory roles in both stomatological disorders and odontogenesis are not yet fully elucidated. Therefore, a systematic review of ATFs-mediated regulatory mechanisms in oral pathologies and odontogenesis would provide critical insights into the molecular mechanisms of ATFs-associated processes in stomatological disorders.

Key words: activating transcription factors, oral pathologies, molecular mechanisms

TIAN Ke, TANG Jing. Research Progress of ATFs Family in Oral Pathologies and Odontogenesis[J]. Journal of Oral Science Research, 2025, 41(11): 941-945.

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