Journal of Oral Science Research

Journal of Oral Science Research ›› 2025, Vol. 41 ›› Issue (11): 993-997.DOI: 10.13701/j.cnki.kqyxyj.2025.11.012

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Promoting of Enamel Remineralization by CPP-CSH After Interproximal Enamel Reduction: An In Vitro Study

LIANG Yuanfan1, DENG Wenzhen2, WANG Ziyi1, HOU Xiaolu1, LIU Chang3, ZHANG Liping4, LIANG Yongqiang1*   

  1. 1. College of Stomatology, North China University of Science and Technology, Tangshan 063210, China;
    2. Affiliated Hospital of Heze Medical College, Heze 274000, China;
    3. Department of Implantology, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China;
    4. Department of Stomatology, Affiliated Hospital of North China University of Science and Technology, Tangshan 063015, China
  • Received:2025-03-27 Online:2025-11-28 Published:2025-11-25

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Abstract: Objective: To investigate the remineralization effect of casein phosphopeptide-calcium silicate hydrate (CPP-CSH) on enamel after interproximal enamel reduction (IER) and evaluate its potential as a safe caries-preventive material. Methods: CPP-CSH solutions at 1%, 3%, and 5% concentrations were prepared. Different concentrations of CPP-CSH solutions were applied to interproximal enamel-reduced tooth surfaces. The oral environment was simulated through pH cycling experiments. The remineralization efficacy was evaluated via energy-dispersive spectroscopy analysis, microhardness testing, and scanning electron microscopy (SEM) to screen the optimal concentration, which was then compared with 10% CSH, Duraphat, and Tooth Mousse. Results: The 1% CPP-CSH group showed the highest Ca/P ratio (P<0.05), significant microhardness improvement (P<0.05), and the smoothest enamel surface with minimal scratches under SEM. The 1% CPP-CSH outperformed 10% CSH (P<0.05) and demonstrated comparable efficacy to Duraphat (P>0.05). Conclusion: 1% CPP-CSH effectively promotes enamel remineralization after IER, offering an alternative to fluoride-based agents and a novel clinical option for post-IER caries prevention.

Key words: interproximal enamel reduction, casein phosphopeptide-calcium silicate hydrate, enamel remineralization, caries prevention