Regulatory Role of Mechanical Stress in Condylar Development

doi:10.13701/j.cnki.kqyxyj.2022.12.001

Abstract

Abstract: The condyle, a growth and development center of the mandible and an important component of the temporomandibular joint, plays a crucial role in physiological activities such as mastication and speech. There are many mandibular deformities caused by abnormal condylar development. These jaw deformities not only affect the appearance and occlusal relationship, but also cause some psychological trauma to young patients. The etiology of abnormal condylar development has drawn significant interest. More and more evidences indicate that abnormal mechanical stress is an important reason of jaw deformity. In this paper, we will summarize the effects of mechanical stress in condylar growth and development, discuss the regulatory role of mechanosensitive ion channels and signaling pathways in condylar development. This review is expected to contribute several ideas for the treatment of dental and maxillofacial malformations.

Key words: mechanical stress, condylar development, asymmetric deformity, ion channels, signaling pathways

YANG Xuewen, LIU Zhan. Regulatory Role of Mechanical Stress in Condylar Development[J]. Journal of Oral Science Research, 2022, 38(12): 1105-1109.

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