Relationship between Expression of CD29 and Pathogenesis of Human Salivary Gland Benign and Malignant Tumors

doi:10.13701/j.cnki.kqyxyj.2018.11.014

Abstract

Abstract: Objective: To analyze and clarify the expression and distribution of various cell surface markers, especially the expression and distribution of CD29 in adult salivary glands. Methods: Paired adult parotid, sublingual and submandibular glands were collected. The phenotypic expression (including CD29) of various family-specific cell surface markers in the collected glands was examined using immunohistochemistry. Results: CD29 was expressed in the salivary gland acinar and duct epithelium, mesenchymal stroma, and myoepithelial cells. CD29⁺ cells were co-expressed in adult salivary gland epithelium with CD324, CD326, NKCC1, and CD44. Mesenchymal cells mainly expressed CD73, CD90, vimentin, and CD34. And α-SMA was the predominantly myoepithelial cell-specific progenitor markers. Conclusion: CD29 is widely expressed in human salivary glands and can be used as a potential biomarker for the treatment and diagnosis of salivary gland diseases and malignant tumors.

Key words: Adult, CD29, Progenitor, Salivary glands, Mesenchymal cells

LIU Xin-can,ZHANG De-bao,LIU Zai-long. Relationship between Expression of CD29 and Pathogenesis of Human Salivary Gland Benign and Malignant Tumors[J]. Journal of Oral Science Research, 2018, 34(11): 1204-1207.

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