Effects of Matrix Metalloproteinase-9 on Bone Development and Remodeling of Postnatal Mice

doi:10.13701/j.cnki.kqyxyj.2019.07.021

Abstract

Abstract: Objective: To investigate the effect of matrix metalloproteinase-9 (MMP-9) on the development and remodeling of femur and craniofacial bone in postnatal mice. Methods: X-ray projection, Micro-CT scanning, three-dimensional imaging, and histological staining were used to observe and analyze the characteristics of bone of MMP-9^-/- mice with wild-type mice at different developmental stages. Results: Compared with the wild-type mice, the femoral trabecular thickness of adult mice was lower than that of wild-type mice. Fat cells were abundant in the bone marrow cavity at 12-week-old MMP-9^-/- mice. The degree of skull mineral density in MMP-9^-/- mice was lower than that of normal mice. Conclusion: MMP-9 gene deletion inhibited the development and remodeling of femoral and craniofacial bones in mice, suggesting that MMP-9 plays an important role in bone development and bone homeostasis.

Key words: matrix metalloproteinase-9, femur, craniofacial bone , development and remodeling

CHAI Jihua, LI Yuqing, YUAN Guohua, ZHANG Yufeng. Effects of Matrix Metalloproteinase-9 on Bone Development and Remodeling of Postnatal Mice[J]. Journal of Oral Science Research, 2019, 35(7): 708-711.

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