In Vitro Drug Release of Dental Flow Resin Modified by Core-shell Shaped CHX/ACP Nanospheres

doi:10.13701/j.cnki.kqyxyj.2019.09.019

Journal of Oral Science Research ›› 2019, Vol. 35 ›› Issue (9): 898-901.DOI: 10.13701/j.cnki.kqyxyj.2019.09.019

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In Vitro Drug Release of Dental Flow Resin Modified by Core-shell Shaped CHX/ACP Nanospheres

XU Zexian^1,2, YANG Yanwei^2,3, QIU Yinong², LI Zhiqiang⁴, WANG Xuefeng¹, WANG Rui¹, ZHENG Xin⁴, LIU Bin^1*

1. School of Stomatology, Lanzhou University, Lanzhou 730050, China;
2. The 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China;
3. State Key Laboratory of Military Stomatology, School of Stomatology, The Air Force Military Medical University, Xi’an 710032, China;
4. Key Lab of Stomatology of State Ethnic Affairs Commission,Key Lab of Oral Diseases of Gansu Province, School of Stomatology, Northwest Minzu University, Lanzhou 730030, China

Received:2019-01-25 Online:2019-09-28 Published:2019-09-25

Abstract

Abstract: Objective: To investigate the in vitro drug release of dental flow resin (FiltekTM Z350XT Flow Resin) modified by chlorhexidine/amorphous calcium phosphate (CHX/ACP) nanospheres with core-shell structure. Methods: The core-shell CHX/ACP nanospheres was synthesized and characterized. Nanospheres were added to FiltekTM Z350XT flow resin in different mass percentages (1%, 5%, and 10%) as experimental group, but unmodified flow resin as control group. The sample leaching solutions were prepared and the releases of calcium, phosphorus, and CHX at different time points were measured. Results: Three groups of experimental resins continuously released calcium, phosphorus, and CHX in deionized water. The release amounts all significantly increased with the increase of the added proportion of nanospheres, and also increased with the prolongation of soaking time. The release rate decreased with time. The release of the control group was approximately zero and did not change with time. Conclusion: Flow resin with different proportions of core-shell CHX/ACP can continuously release calcium,phosphorus, and CHX slowly. The addition proportion of nanoparticles has a significant effect on drug release.

Key words: anospheres with core-shell structure, chlorhexidine, amorphous calcium phosphate, dental flow resin

XU Zexian, YANG Yanwei, QIU Yinong, LI Zhiqiang, WANG Xuefeng, WANG Rui, ZHENG Xin, LIU Bin. In Vitro Drug Release of Dental Flow Resin Modified by Core-shell Shaped CHX/ACP Nanospheres[J]. Journal of Oral Science Research, 2019, 35(9): 898-901.

References

[1] Cheng L, Zhang K, Weir MD, et al. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries [J]. Nanomedicine (Lond), 2015, 10(4):627-641.
[2] Xiao Z, Que K, Wang H, et al. Rapid biomimetic remineralization of the demineralized enamel surface using nano-particles of amorphous calcium phosphate guided by chimaeric peptides [J]. Dent Mater, 2017, 33(11):1217-1228.
[3] Zhang JF, Wu R, Fan Y, et al. Antibacterial dental composites with chlorhexidine and mesoporous silica [J]. J Dent Res, 2014, 93(12):1283-1289.
[4] He W, Tao J, Pan H, et al. A size-controlled synthesis of hollow apatite nanospheres at water-oil interfaces [J]. Chem Lett, 2010, 39(7):674-675.
[5] 北京大学口腔医学院.缓释氯己定无定形磷酸钙纳米颗粒的制备方法:CN201410486872.3[P].2015-08-26.
[6] Yang YW, Yu F, Zhang HC, et al. Physicochemical properties and cytotoxicity of an experimental resin-based pulp capping material containing the quaternary ammonium salt and Portland cement [J].Int Endod J, 2018, 51(1):26-40.
[7] Wu Y, Yang Y, Liu H, et al. Long-term antibacterial protected cotton fabric coating by controlled release of chlorhexidine gluconate from halloysite nanotubes [J]. Rsc Advances, 2017, 7(31):18917-18925.
[8] Liang K, Xiao S, Wu J, et al. Long-term dentin remineralization by poly(amido amine) and rechargeable calcium phosphate nanocomposite after fluid challenges [J]. Dent Mater,2018,34(4):607-618.
[9] 叶倩琳,李祯,曹茜茜,等.自组装纳米粒子防龋疫苗的免疫效能[J].口腔医学研究,2017,33(10):1023-1026.
[10] Jeong U, Wang Y, Ibisate M, et al. Some new developments in the synthesis, functionalization, and utilization of monodisperse colloidal spheres [J]. Advanced Functional Materials, 2010, 15(12):1907-1921.
[11] Niu X, Chen S, Tian F, et al. Hydrolytic conversion of amorphous calcium phosphate into apatite accompanied by sustained calcium and orthophosphate ions release [J]. Mater Sci Eng C Mater Biol Appl, 2017, 70(Pt 2):1120-1124.
[12] Campbell AA, Song L, Li XS, et al. Development, characterization, and anti-microbial efficacy of hydroxyapatite-chlorhexidine coatings produced by surface-induced mineralization [J]. J Biomed Mater Res B, 2015, 53(4):400-407.
[13] Xu HH, Weir MD, Sun L, et al. Strong nanocomposites with CaPO₄, and F release for caries inhibition [J]. J Dent Res, 2010, 89(1):19-28.
[14] Natale LC, Rodrigues MC, Yvette A, et al. Mechanical characterization and ion release of bioactive dental composites containing calcium phosphate particles [J]. J Mech Behav Biomed Mater, 2018, 84:161-167.

In Vitro Drug Release of Dental Flow Resin Modified by Core-shell Shaped CHX/ACP Nanospheres

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