Abstract: Objective: To observe the postoperative analgesic effect of nbuphine combined with sufentanil on patients with maxillofacial fractures and the changes of inflammatory factors. Methods: Eighty patients with postoperative intravenous controlled analgesia in our hospital from August 2019 to November 2019 with maxillofacial fractures were randomly divided into control group and study group (40 patients in each group). At different time points after surgery, visual analog pain score, Ramsay sedation score, after 48h self-control analgesia in patients with total number of press number and press, satisfaction, c-reactive protein and calcitonin original in the peripheral blood, and the quality of life score were analyzed. Results: VAS scores and RSS scores of the two groups were insignificant after 2h of administration, while the study group was significantly better than the control group after 4 h, 8 h, 12 h, 24 h, and 48 h of administration. The total number of postoperative compressions and effective compressions in the study group were lower than those in the control group. The satisfaction of the study group was better than that of the control group. There was no statistically significant difference between the two groups in c-reactive protein and procalcitonin before operation (P>0.05). The quality of life score of the study group was better than that of the control group. Conclusion: Nabuphine combined with sufentanil can significantly enhance the postoperative analgesic effect, reduce the level of inflammatory factors in the body, and improve patient satisfaction and living standard, which is worthy of clinical application.

Key words: nalbuphine, sufentanil, maxillofacial fracture, C-reactive protein, procalcitonin