Abstract: Objective: To compare the effects of systemic and topical medication on PCT and CRP after oral dental implantation surgery. Methods: Totally 120 patients with dentition defect, who undenwent the dental implantation surgery from January 2014 to November 2015, were included and randomly divided into the systemic medication group and the topical medication group. Patients in systemic group were given ornidazole treatment, while patients in local group were given minocycline treatment around the implant or inside the incision. The levels of PCT and CRP before and after treatment and the postoperative pain and curative effects were compared. Results: The total effective rate in local group was 95.0%, which was significantly higher than 83.3% of general group (P<0.05). When compared the incidence of postoperative pain, the topical group (41.7%) was significantly superior to the general group (60.0%). Conclusion: The topical administration of minocycline hydrochloride is superior to the systemic administration on the prevention of infection after the dental implantation surgery.