Journal of Oral Science Research

Journal of Oral Science Research ›› 2017, Vol. 33 ›› Issue (12): 1306-1309.DOI: 10.13701/j.cnki.kqyxyj.2017.12.017

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Metabonomics Study on Peri-implant Mucositis before and after Drug Intervention.

ZHANG Yu-shi1,2, SHAO Yan-lin3, LU Shuai2, ZHONG Ke1,2*.   

  1. 1.School of Stomatology, Southwest Medical University, Luzhou 646000, China;
    2. Authority Hospital of Chengdu Military Region, Chengdu 610041, China;
    3. Nanchong Central Hospital of Stomatology, Nanchong 637000,China.
  • Received:2017-07-24 Online:2017-12-20 Published:2018-01-03

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Abstract: Objective: To discuss the gingival sulcus fluid (GCF) metabolomics characteristics and metabolic product difference in peri-implant mucositis before and after drug (minocycline hydrochloride) intervention, and to find the implant mucositis potential biomarkers. Methods: Thirty patients receiving dental implant were recruited and divided into group A (health implant), group B (peri-implant mucositis), and group C (drug intervention), with 15 cases in group A, 15 cases in group B and group C. Five cases were randomly selected from each group. GCF was collected and analyzed with UHPLC/Q-TOF-MS instrument. The results were compared accurately with online database Metlin Library and human metabolites database (HMDB). Results: There were 10, 5, and 4 different metabolites between A and B, B and C, and A and C (P<0.05). Conclusion: Hemolytic phosphatidyl choline and haemolytic phosphatidyl ethanolamine might be potential marker for the peri-implant mucositis.

Key words: Peri-implant mucositis , Ultra high performance liquid chromatography , Quadrupole-time-of-flight-mass spectrometry, Metabonomics

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