Advances in Use of Deep-frozen Allogeneic Bone in Repair of Oral and Maxillofacial Bone Defects

doi:10.13701/j.cnki.kqyxyj.2025.09.003

Abstract

Abstract: Autologous bone is the 'gold standard' for the repair of oral and maxillofacial bone defects. However, autogenous bone grafting requires the creation of a second surgical area and has limited bone volume. Allograft bone is considered to be a good alternative to autogenous bone because of its good osteoconductivity and osteogenesis. Deep frozen allogeneic bone is a bone substitute material that stored at -80 ℃ for a long period of time after deep cryogenic freezing and irradiation, which has similar osteogenic effect and mechanical properties as autogenous bone, and has been widely used in the fields of surgery and oral and maxillofacial surgery in recent years. This paper summarizes the research progress and clinical application of deep-frozen allograft in the field of oral and maxillofacial bone repair in the past decade, covering the preparation technology of deep-frozen allograft, the progress of basic research, and the clinical application of deep-frozen bone in the repair of oral and maxillofacial bone defects and its cinical application effect.

Key words: allograft bone, alveolar ridge defect, bone augmentation, maxillary sinus lift, bone grafting

TANG Qingwei, YANG Fan. Advances in Use of Deep-frozen Allogeneic Bone in Repair of Oral and Maxillofacial Bone Defects[J]. Journal of Oral Science Research, 2025, 41(9): 750-754.

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