Retrospective Study on Application of L-PRF in Extraction of Mandibular Third Molars with Different Levels of Difficulty

doi:10.13701/j.cnki.kqyxyj.2026.01.007

Abstract

Abstract: Objective: To investigate the effects of leukocyte-platelet-rich fibrin (L-PRF) on postoperative pain, swelling, and soft tissue healing following extraction of mandibular third molars with varying difficulty levels. Methods: This retrospective study analyzed 146 consecutive cases of mandibular third molar extraction performed at our institution between November 2021 and October 2022. Patients were stratified into two groups based on surgical records: the PRF group (receiving L-PRF placement in the extraction socket) and the control group (undergoing natural healing without biomaterial intervention). Comparative assessments of postoperative pain, swelling, and soft tissue healing parameters were conducted between the groups. Results: The PRF group exhibited statistically significant reductions in both pain and swelling scores at postoperative days 1, 2, and 3 compared to the control group (P<0.05). Furthermore, the PRF group demonstrated superior soft tissue healing outcomes at day 7 postoperatively, as evidenced by significantly lower healing index scores (P<0.01). These therapeutic advantages were particularly pronounced in cases of moderate surgical difficulty (P<0.05). Conclusion: L-PRF application yields optimal clinical benefits in moderately difficult mandibular third molar extractions, demonstrating significant efficacy in mitigating postoperative pain and swelling while promoting enhanced soft tissue healing.

Key words: leukocyte-and platelet-rich fibrin, third molar, pain, swelling, soft tissue healing

BU Keyu, HU Haichun, HUANG Xuhan, OUYANG Junyi, ZOU Haixiao. Retrospective Study on Application of L-PRF in Extraction of Mandibular Third Molars with Different Levels of Difficulty[J]. Journal of Oral Science Research, 2026, 42(1): 35-40.

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