Abstract: Objective: To investigate the effects of midazolam on anxiety levels and salivary cortisol levels in children after intranasal and sublingual midazolam, and to explore the possibility of mild sedation in Department of Pediatric Stomatology. Methods: Eighty-two patients with 3-7 years old were included in this study and were randomly divided into two groups. Patients received intranasal or sublingual midazolam at the 30 minutes prior to oral treatment. The anxiety levels were assessed using Venham clinical anxiety scale per 5 minutes and salivary cortisol levels were assessed 30 minutes before and after administration. Results: There was a significant decrease in the anxiety level from T0 to T1-T4 in group A and group B (P＜0.05). There was no significant difference between two groups in the levels of salivary cortisol before and after taking the medicine. Conclusion: Midazolam can effectively relieve anxiety in children patients and has no effect on salivary cortisol levels. The tongue way was better absorption than the nasal route.

Key words: Midazolam, Dental anxiety, Child patient, Cortisol