Degradation of Polylactic Acid/hydroxyapatite CompositePrimary Teeth Post in Vitro.

doi:10.13701/j.cnki.kqyxyj.2017.01.005

Abstract

Abstract: Objective: To evaluate the degradation in vitro of polylactic acid/hydroxyapatite (PLA/HA) compositesprimary teeth post. Methods: According to the Chinese standard for biological evaluation of medical devices, the PLA/HA and PLA were immersed in phosphate buffer liquid (PBS) and distilled water, and a series of tests were performed with specimens in vitro at different time points respectively to evaluate the degradation in vitro of PLA/HA. Results: Macroscopic observation showed that the specimen color turned to white gradually and appeared micro cracks. The SEM results showed that the HA particles became smaller and PLA appeared sizes pore with the extension of degradation time. The molecular weight of PLA/HA and PLA decreased gradually and its elastic modulus and bending strength attenuated. The pH values of PLA/HA and PLA degradation solutions reduced gradually and that of PLA was falling faster than that of PLA/HA. Conclusion: The PLA/HA has a certain degradation performance, and its mechanical strength can keep primary teeth bite force in the ten months of observation.

Key words: Polylactic, acid/hydroxyapatite, Primary, teeth, root, canal, post, Degradation, in, vitro

CLC Number:

R788⁺.1

ZHANG Lu-lu, GAI Li-ting, XU Gao-xiang, YANG Xue, GAO Hua-li, JIANG Qiu.. Degradation of Polylactic Acid/hydroxyapatite CompositePrimary Teeth Post in Vitro.[J]. Journal of Oral Science Research, 2017, 33(1): 19-23.

References

[1] Lee BK, Yun Y, Park K. PLA Micro-and Nano-Particles [J]. Advanced Drug Delivery Reviews, 2016,48(4)∶627-635
[2] Lopes MS, Jardini AL, Maciel FR. Poly(lactic acid) production for tissue engineering applications [J]. ProcediaEngineering,2012,42(10)∶1402-1413
[3] 孙莹,李正强,刘炜炜,等.丝素蛋白/左旋聚乳酸支架材料与软骨细胞体外细胞相容性研究[J].口腔医学研究,2015,31(3)∶221-224
[4] 盖立婷,徐高祥,张鲁鲁,等.聚乳酸/羟基磷灰石(PLLA/HA)复合物预成乳前牙根管桩的生物相容性研究[J].口腔医学研究,2015,31(11)∶1073-1075
[5] Kalita SJ, Bhardwaj A, Bhatt HA. Nanocrystalline calcium phosphate ceramics in biomedical engineering.Materials Sci Eng C, 2007, 27(4)∶441-449
[6] 林山, 黄晓梅, 芮钢, 等.数字化珊瑚羟基磷灰石人工骨支架的体外降解性能[J].中国组织工程研究,2016,20(3)∶330-335
[7] Pihlajamki H, Bstman O, Tynninen O, et al. Long-term tissue response to bioabsorbable poly-L-lactide and metallic screws: an experimental study [J]. Bone, 2006, 39(4)∶932-937
[8] babu Valapa R, Pugazhenthi G, Katiyar V. Hydrolytic degradation behaviour of sucrose palmitate reinforced poly (lactic acid) nanocomposites [J]. International journal of biological macromolecules, 2016, 89(1)∶70-80
[9] Nair NR, Sekhar VC, Nampoothiri KM. Augmentation of a Microbial Consortium for Enhanced Polylactide (PLA) Degradation [J]. Indian Journal of Microbiology, 2016, 56(1)∶59-63
[10] 黄福龙,戴红莲,方园,等.HA/PDLLA 复合材料的制备及其降解性能研究[J].无机材料学报,2007,22(2)∶333-338
[11] Verheyen C, De Wijn JR, Van Blitterswijk CA, et al. Hydroxylapatite/poly (L‐lactide) composites: An animal study on push‐out strengths and interface histology [J]. Journal of biomedical materials research, 1993, 27(4)∶433-444
[12] Cheung W. A review of the management of endodontically treated teeth: post, core and the final restoration [J]. The Journal of the American Dental Association, 2005, 136(5)∶611-619
[13] Goto Y, Nicholls JI, Phillips KM, et al. Fatigue resistance of endodontically treated teeth restored with three dowel-and-core systems [J]. The Journal of prosthetic dentistry, 2005, 93(1)∶45-50
[14] 王亚林,朱玲,张静露.儿童牙合接触面积及牙合力的研究[J].中国儿童保健杂志,2006,14(6)∶637-638

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